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- W3210199624 abstract "T-cell Acute Lymphoblastic Leukemia (T-ALL) accounts for around 10–15% of all lymphoblastic leukemia in children. Previous studies have proven that dysregulation of Leukemia-induced non-coding activator RNA-1 (LUNAR1) expression promotes T-ALL cell growth by enhancing the NOTCH1/IGF-1R signaling pathway. We aimed to investigate the prognostic value of LUNAR1 in pediatric T-ALL, in addition, to find out its association with NOTCH1 and IGF-1R. The LUNAR1, NOTCH1, and IGF-IR gene expression were measured in peripheral blood (PB) samples of l85 children with T-ALL and forty non-leukemic samples as a control group. Cox regression analysis revealed that overexpression of LUNAR1, NOTCH1, and IGF-IR was significantly correlated with poor prognosis, short overall survival, and progression-free survival. We concluded that LUNAR1 could serve as an independent prognostic biomarker for T-ALL in children." @default.
- W3210199624 created "2021-11-08" @default.
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- W3210199624 date "2021-11-01" @default.
- W3210199624 modified "2023-09-27" @default.
- W3210199624 title "Upregulation of leukemia-induced non-coding activator RNA (LUNAR1) predicts poor outcome in pediatric T-acute lymphoblastic leukemia" @default.
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- W3210199624 doi "https://doi.org/10.1016/j.imbio.2021.152149" @default.
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