FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210208045> ?p ?o ?g. }

• W3210208045 endingPage "988" @default.
• W3210208045 startingPage "979" @default.
• W3210208045 abstract "For medication control in several jurisdictions, withdrawal time is the period of refrain from racing after drug administration. It is set by adding a safety period to an experimental detection time. However, there are no reports of statistical analyses of detection time for the determination of withdrawal time in flunixin meglumine-treated horses.To analyse the population pharmacokinetics of flunixin in horses through the generation of a dataset for detection time statistical analysis and predictions via Monte Carlo simulation.Experimental study.Drug plasma and urine concentrations following single intravenous administration of flunixin 1.1 mg/kg bodyweight (BW) in 10 horses and multiple administration of q 24 hours for 5 days in 10 horses were measured using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Data were modelled using a nonlinear mixed effect model followed by Monte Carlo simulation. Irrelevant plasma concentration (IPC) and irrelevant urine concentration (IUC) were calculated using the Toutain approach. Detection times were obtained considering the time after the last administration for selected quantiles of 5000 hypothetical horses under the international screening limit (ISL) proposed by the International Federation of Horseracing Authorities (plasma: 1 ng/mL, urine; 100 ng/mL).For a regimen of 1.1 mg/kg BW q 24 hours, the IPC and IUC values were 2.0 and 73.0 ng/mL respectively. Detection times in plasma above the ISL for 90% of simulated horses were estimated as 74 hours after a single 1.1 mg/kg dose administration, 149 and 199 hours after multiple doses over 5 days at either 24- or 12-hour intervals respectively. Corresponding detection times in urine were 46, 68 and 104 hours respectively.Only female horses were investigated.Statistical detection times for different flunixin meglumine regimens indicated a delay of detection time in plasma after multiple administrations under ISL." @default.
• W3210208045 created "2021-11-08" @default.
• W3210208045 creator A5003301522 @default.
• W3210208045 creator A5017603302 @default.
• W3210208045 creator A5032572523 @default.
• W3210208045 creator A5039070216 @default.
• W3210208045 creator A5043798297 @default.
• W3210208045 creator A5044933330 @default.
• W3210208045 creator A5045196987 @default.
• W3210208045 creator A5051839246 @default.
• W3210208045 creator A5068840921 @default.
• W3210208045 creator A5074930023 @default.
• W3210208045 creator A5081204074 @default.
• W3210208045 creator A5090205715 @default.
• W3210208045 creator A5091551910 @default.
• W3210208045 date "2021-11-25" @default.
• W3210208045 modified "2023-10-17" @default.
• W3210208045 title "Medication control of flunixin in racing horses: Possible detection times using Monte Carlo simulations" @default.
• W3210208045 cites W1442751115 @default.
• W3210208045 cites W1508197891 @default.
• W3210208045 cites W1711873743 @default.
• W3210208045 cites W188477751 @default.
• W3210208045 cites W1989102568 @default.
• W3210208045 cites W2003863166 @default.
• W3210208045 cites W202202644 @default.
• W3210208045 cites W202211084 @default.
• W3210208045 cites W2037714321 @default.
• W3210208045 cites W2069208574 @default.
• W3210208045 cites W2075989451 @default.
• W3210208045 cites W2077596682 @default.
• W3210208045 cites W2081503464 @default.
• W3210208045 cites W2109108975 @default.
• W3210208045 cites W2130652541 @default.
• W3210208045 cites W2154158699 @default.
• W3210208045 cites W2156045968 @default.
• W3210208045 cites W2163725624 @default.
• W3210208045 cites W2169667658 @default.
• W3210208045 cites W2172261908 @default.
• W3210208045 cites W2408008915 @default.
• W3210208045 cites W2409020836 @default.
• W3210208045 cites W2411375059 @default.
• W3210208045 cites W2884354986 @default.
• W3210208045 cites W2914785590 @default.
• W3210208045 cites W2982499691 @default.
• W3210208045 cites W3210208045 @default.
• W3210208045 cites W4243179205 @default.
• W3210208045 cites W6838119 @default.
• W3210208045 doi "https://doi.org/10.1111/evj.13532" @default.
• W3210208045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34719043" @default.
• W3210208045 hasPublicationYear "2021" @default.
• W3210208045 type Work @default.
• W3210208045 sameAs 3210208045 @default.
• W3210208045 citedByCount "4" @default.
• W3210208045 countsByYear W32102080452021 @default.
• W3210208045 countsByYear W32102080452023 @default.
• W3210208045 crossrefType "journal-article" @default.
• W3210208045 hasAuthorship W3210208045A5003301522 @default.
• W3210208045 hasAuthorship W3210208045A5017603302 @default.
• W3210208045 hasAuthorship W3210208045A5032572523 @default.
• W3210208045 hasAuthorship W3210208045A5039070216 @default.
• W3210208045 hasAuthorship W3210208045A5043798297 @default.
• W3210208045 hasAuthorship W3210208045A5044933330 @default.
• W3210208045 hasAuthorship W3210208045A5045196987 @default.
• W3210208045 hasAuthorship W3210208045A5051839246 @default.
• W3210208045 hasAuthorship W3210208045A5068840921 @default.
• W3210208045 hasAuthorship W3210208045A5074930023 @default.
• W3210208045 hasAuthorship W3210208045A5081204074 @default.
• W3210208045 hasAuthorship W3210208045A5090205715 @default.
• W3210208045 hasAuthorship W3210208045A5091551910 @default.
• W3210208045 hasBestOaLocation W32102080452 @default.
• W3210208045 hasConcept C105795698 @default.
• W3210208045 hasConcept C112705442 @default.
• W3210208045 hasConcept C126322002 @default.
• W3210208045 hasConcept C19499675 @default.
• W3210208045 hasConcept C2780026642 @default.
• W3210208045 hasConcept C33923547 @default.
• W3210208045 hasConcept C71924100 @default.
• W3210208045 hasConcept C98274493 @default.
• W3210208045 hasConceptScore W3210208045C105795698 @default.
• W3210208045 hasConceptScore W3210208045C112705442 @default.
• W3210208045 hasConceptScore W3210208045C126322002 @default.
• W3210208045 hasConceptScore W3210208045C19499675 @default.
• W3210208045 hasConceptScore W3210208045C2780026642 @default.
• W3210208045 hasConceptScore W3210208045C33923547 @default.
• W3210208045 hasConceptScore W3210208045C71924100 @default.
• W3210208045 hasConceptScore W3210208045C98274493 @default.
• W3210208045 hasFunder F4320315566 @default.
• W3210208045 hasIssue "5" @default.
• W3210208045 hasLocation W32102080451 @default.
• W3210208045 hasLocation W32102080452 @default.
• W3210208045 hasLocation W32102080453 @default.
• W3210208045 hasLocation W32102080454 @default.
• W3210208045 hasLocation W32102080455 @default.
• W3210208045 hasOpenAccess W3210208045 @default.
• W3210208045 hasPrimaryLocation W32102080451 @default.
• W3210208045 hasRelatedWork W1979597421 @default.
• W3210208045 hasRelatedWork W2007980826 @default.
• W3210208045 hasRelatedWork W2141289501 @default.

• next