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- W3210208747 abstract "Spinal cord injury (SCI) is one of the leading causes of disability in Military personnel for which no suitable therapeutic strategies are available till today. Thus, exploration of novel therapeutic measures is highly needed to enhance the quality of life of SCI victims. Previously, topical application of BDNF and GDNF in combination over the injured spinal cord after 90min induced marked neuroprotection. In present investigation, we added CNTF in combination with BDNF and/or GDNF treatment to examine weather the triple combination applied over the traumatic cord after 90 or 120min could thwart cord pathology. Since neurotrophins attenuate nitric oxide (NO) production in SCI, the role of carbon monoxide (CO) production that is similar to NO in inducing cell injury was explored using immunohistochemistry of the constitutive isoform of enzyme hemeoxygenase-2 (HO-2). SCI inflicted over the right dorsal horn of the T10-11 segments by making an incision of 2mm deep and 5mm long upregulated the HO-2 immunostaining in the T9 and T12 segments after 5h injury. These perifocal segments are associated with breakdown of the blood-spinal cord barrier (BSCB), edema development and cell injuries. Topical application of CNTF with BDNF and GDNF in combination (10ng each) after 90 and 120min over the injured spinal cord significantly attenuated the BSCB breakdown, edema formation, cell injury and overexpression of HO-2. These observations are the first to show that CNTF with BDNF and GDNF induced superior neuroprotection in SCI probably by downregulation of CO production, not reported earlier." @default.
- W3210208747 created "2021-11-08" @default.
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- W3210208747 date "2021-01-01" @default.
- W3210208747 modified "2023-10-18" @default.
- W3210208747 title "Topical application of CNTF, GDNF and BDNF in combination attenuates blood-spinal cord barrier permeability, edema formation, hemeoxygenase-2 upregulation, and cord pathology" @default.
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- W3210208747 cites W1607718945 @default.
- W3210208747 cites W1697717000 @default.
- W3210208747 cites W173718877 @default.
- W3210208747 cites W1855504544 @default.
- W3210208747 cites W1885019466 @default.
- W3210208747 cites W1944647947 @default.
- W3210208747 cites W1965790042 @default.
- W3210208747 cites W1968611586 @default.
- W3210208747 cites W1979174938 @default.
- W3210208747 cites W1990887043 @default.
- W3210208747 cites W1991628249 @default.
- W3210208747 cites W1996212130 @default.
- W3210208747 cites W1999311858 @default.
- W3210208747 cites W2004276842 @default.
- W3210208747 cites W2006257074 @default.
- W3210208747 cites W2009556099 @default.
- W3210208747 cites W2009582310 @default.
- W3210208747 cites W2011725743 @default.
- W3210208747 cites W2022217336 @default.
- W3210208747 cites W2025199687 @default.
- W3210208747 cites W2033571549 @default.
- W3210208747 cites W2034159650 @default.
- W3210208747 cites W2035564103 @default.
- W3210208747 cites W2050858813 @default.
- W3210208747 cites W2057838550 @default.
- W3210208747 cites W2064981768 @default.
- W3210208747 cites W2075777731 @default.
- W3210208747 cites W2081896728 @default.
- W3210208747 cites W2083472765 @default.
- W3210208747 cites W2084703893 @default.
- W3210208747 cites W2110402374 @default.
- W3210208747 cites W2123909846 @default.
- W3210208747 cites W2133601552 @default.
- W3210208747 cites W2140031741 @default.
- W3210208747 cites W2161476725 @default.
- W3210208747 cites W2163586674 @default.
- W3210208747 cites W2202914076 @default.
- W3210208747 cites W2278018060 @default.
- W3210208747 cites W2402384745 @default.
- W3210208747 cites W2417368033 @default.
- W3210208747 cites W2463348012 @default.
- W3210208747 cites W2612033544 @default.
- W3210208747 cites W2725950495 @default.
- W3210208747 cites W2765783388 @default.
- W3210208747 cites W2781038005 @default.
- W3210208747 cites W2883196852 @default.
- W3210208747 cites W2885885948 @default.
- W3210208747 cites W2903305972 @default.
- W3210208747 cites W2907994340 @default.
- W3210208747 cites W2909073319 @default.
- W3210208747 cites W2921062954 @default.
- W3210208747 cites W2947270015 @default.
- W3210208747 cites W2957073165 @default.
- W3210208747 cites W2989852131 @default.
- W3210208747 cites W3009268606 @default.
- W3210208747 cites W3010305229 @default.
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- W3210208747 cites W431362998 @default.
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- W3210208747 doi "https://doi.org/10.1016/bs.pbr.2021.06.013" @default.
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