FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210244313> ?p ?o ?g. }

• W3210244313 endingPage "1766" @default.
• W3210244313 startingPage "1759" @default.
• W3210244313 abstract "Vasogenic edema results from blood-brain barrier (BBB) disruption after traumatic brain injury (TBI), and although it can be fatal, no promising therapeutic drugs have been developed as yet. Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable channel that is sensitive to temperature and osmotic pressure. As TRPV4 is known to be responsible for various pathological conditions following brain injury, we investigated the effects of pharmacological TRPV4 antagonists on TBI-induced vasogenic edema in this study. A TBI model was established by inflicting fluid percussion injury (FPI) in the mouse cerebrum and cultured astrocytes. Vasogenic brain edema and BBB disruption were assessed based on brain water content and Evans blue (EB) extravasation into brain tissue, respectively. After FPI, brain water content and EB extravasation increased. Repeated intracerebroventricular administration of the specific TRPV4 antagonists HC-067047 and RN-1734 dose-dependently reduced brain water content and alleviated EB extravasation in FPI mice. Additionally, real-time PCR analysis indicated that administration of HC-067047 and RN-1734 reversed the FPI-induced increase in mRNA levels of endogenous causal factors for BBB disruption, including matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor-A (VEGF-A), and endothelin-1 (ET-1). In astrocytes, TRPV4 level was observed to be higher than that in brain microvascular endothelial cells. Treatment with HC-067047 and RN-1734 inhibited the increase in mRNA levels of MMP-9, VEGF-A, and ET-1 in cultured astrocytes subjected to in vitro FPI. These results suggest that pharmacological inhibition of TRPV4 is expected to be a promising therapeutic strategy for treating TBI-induced vasogenic edema." @default.
• W3210244313 created "2021-11-08" @default.
• W3210244313 creator A5006183918 @default.
• W3210244313 creator A5034262525 @default.
• W3210244313 creator A5039434669 @default.
• W3210244313 creator A5058500799 @default.
• W3210244313 creator A5085640969 @default.
• W3210244313 date "2021-11-01" @default.
• W3210244313 modified "2023-10-11" @default.
• W3210244313 title "Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice" @default.
• W3210244313 cites W1493831502 @default.
• W3210244313 cites W1519585367 @default.
• W3210244313 cites W1995785702 @default.
• W3210244313 cites W2003890250 @default.
• W3210244313 cites W2008479646 @default.
• W3210244313 cites W2013399980 @default.
• W3210244313 cites W2019778468 @default.
• W3210244313 cites W2029048308 @default.
• W3210244313 cites W2057974205 @default.
• W3210244313 cites W2065232910 @default.
• W3210244313 cites W2073576822 @default.
• W3210244313 cites W2086448856 @default.
• W3210244313 cites W2094458351 @default.
• W3210244313 cites W2098841206 @default.
• W3210244313 cites W2100557964 @default.
• W3210244313 cites W2105443363 @default.
• W3210244313 cites W2111982133 @default.
• W3210244313 cites W2128440535 @default.
• W3210244313 cites W2169454631 @default.
• W3210244313 cites W2170724437 @default.
• W3210244313 cites W2323939613 @default.
• W3210244313 cites W2560014610 @default.
• W3210244313 cites W2608107406 @default.
• W3210244313 cites W2623218438 @default.
• W3210244313 cites W2627401075 @default.
• W3210244313 cites W2784015117 @default.
• W3210244313 cites W2802588136 @default.
• W3210244313 cites W2804202862 @default.
• W3210244313 cites W2884424144 @default.
• W3210244313 cites W2898523507 @default.
• W3210244313 cites W2946016906 @default.
• W3210244313 cites W2960774789 @default.
• W3210244313 cites W2999662108 @default.
• W3210244313 cites W3012721989 @default.
• W3210244313 cites W3021573204 @default.
• W3210244313 cites W3036279865 @default.
• W3210244313 cites W3036506251 @default.
• W3210244313 cites W583881585 @default.
• W3210244313 doi "https://doi.org/10.1248/bpb.b21-00512" @default.
• W3210244313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34719652" @default.
• W3210244313 hasPublicationYear "2021" @default.
• W3210244313 type Work @default.
• W3210244313 sameAs 3210244313 @default.
• W3210244313 citedByCount "6" @default.
• W3210244313 countsByYear W32102443132022 @default.
• W3210244313 countsByYear W32102443132023 @default.
• W3210244313 crossrefType "journal-article" @default.
• W3210244313 hasAuthorship W3210244313A5006183918 @default.
• W3210244313 hasAuthorship W3210244313A5034262525 @default.
• W3210244313 hasAuthorship W3210244313A5039434669 @default.
• W3210244313 hasAuthorship W3210244313A5058500799 @default.
• W3210244313 hasAuthorship W3210244313A5085640969 @default.
• W3210244313 hasBestOaLocation W32102443131 @default.
• W3210244313 hasConcept C118552586 @default.
• W3210244313 hasConcept C126322002 @default.
• W3210244313 hasConcept C134018914 @default.
• W3210244313 hasConcept C142724271 @default.
• W3210244313 hasConcept C155164980 @default.
• W3210244313 hasConcept C170493617 @default.
• W3210244313 hasConcept C2777649898 @default.
• W3210244313 hasConcept C2778402981 @default.
• W3210244313 hasConcept C2779493303 @default.
• W3210244313 hasConcept C2779540182 @default.
• W3210244313 hasConcept C2780886150 @default.
• W3210244313 hasConcept C2781017439 @default.
• W3210244313 hasConcept C42219234 @default.
• W3210244313 hasConcept C529278444 @default.
• W3210244313 hasConcept C71924100 @default.
• W3210244313 hasConcept C90420996 @default.
• W3210244313 hasConcept C98274493 @default.
• W3210244313 hasConceptScore W3210244313C118552586 @default.
• W3210244313 hasConceptScore W3210244313C126322002 @default.
• W3210244313 hasConceptScore W3210244313C134018914 @default.
• W3210244313 hasConceptScore W3210244313C142724271 @default.
• W3210244313 hasConceptScore W3210244313C155164980 @default.
• W3210244313 hasConceptScore W3210244313C170493617 @default.
• W3210244313 hasConceptScore W3210244313C2777649898 @default.
• W3210244313 hasConceptScore W3210244313C2778402981 @default.
• W3210244313 hasConceptScore W3210244313C2779493303 @default.
• W3210244313 hasConceptScore W3210244313C2779540182 @default.
• W3210244313 hasConceptScore W3210244313C2780886150 @default.
• W3210244313 hasConceptScore W3210244313C2781017439 @default.
• W3210244313 hasConceptScore W3210244313C42219234 @default.
• W3210244313 hasConceptScore W3210244313C529278444 @default.
• W3210244313 hasConceptScore W3210244313C71924100 @default.
• W3210244313 hasConceptScore W3210244313C90420996 @default.
• W3210244313 hasConceptScore W3210244313C98274493 @default.
• W3210244313 hasIssue "11" @default.

• next