FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210245289> ?p ?o ?g. }

• W3210245289 abstract "Enterotoxigenic Escherichia coli (ETEC) is a common enteric pathogen that causes diarrhoea in humans and animals. Lactobacillus rhamnosus LB1 (formerly named Lactobacillus zeae LB1) has been shown to reduce ETEC infection to Caenorhabditis elegans and Salmonella burden in pigs. This study was to evaluate the effect of L. rhamnosus LB1 on the gut health of lactating piglets that were challenged with ETEC. Six-four piglets at 7 days of age were equally assigned into 8 groups (8 piglets per group): 1) control group (basal diet, phosphate buffer saline); 2) CT group (basal diet + 40 mg/kg colistin); 3) LL group (basal diet + 1 × 107 CFU/pig/day LB1); 4) HL group (basal diet + 1 × 108 CFU/pig/day LB1); 5) ETEC group: (basal diet + ETEC challenged); 6) CT + ETEC group (basal diet + CT + ETEC); 7) LL + ETEC group (basal diet + 1 × 107 CFU/pig/day LB1 + ETEC); 8) HL + ETEC group (basal diet + 1 × 108 CFU/pig/day LB1 + ETEC). The trial lasted ten days including 3 days of adaptation. Several significant interactions were found on blood parameters, intestinal morphology, gene, and protein expression. ETEC infection disrupted the cell structure and biochemical indicators of blood, undermined the integrity of the intestinal tract, and induced oxidative stress, diarrhoea, intestinal damage, and death of piglets. The supplementation of L. rhamnosus LB1 alleviated ETEC's adverse effects by reducing pig diarrhoea, oxidative stress, and death, modulating cell structure and biochemical indicators of blood, improving the capacity of immunity and anti-oxidation stress of pigs, and restoring their intestinal integrity. At the molecular level, the beneficial effects of L. rhamnosus LB1 appeared to be mediated by regulating functional related proteins (including HSP70, Caspase-3, NLRP3, AQP3, and AQP4) and genes (including RPL4, IL-8, HP, HSP70, Mx1, Mx2, S100A12, Nrf2, GPX2 and ARG1). These results suggest that dietary supplementation of L. rhamnosus LB1 improved the intestinal functions and health of piglets." @default.
• W3210245289 created "2021-11-08" @default.
• W3210245289 creator A5010316221 @default.
• W3210245289 creator A5021364942 @default.
• W3210245289 creator A5022984104 @default.
• W3210245289 creator A5026470906 @default.
• W3210245289 creator A5044939434 @default.
• W3210245289 creator A5053204257 @default.
• W3210245289 creator A5056807970 @default.
• W3210245289 creator A5071869550 @default.
• W3210245289 creator A5073216396 @default.
• W3210245289 creator A5078348179 @default.
• W3210245289 creator A5078526337 @default.
• W3210245289 date "2021-11-02" @default.
• W3210245289 modified "2023-10-16" @default.
• W3210245289 title "Lactobacillus rhamnosus LB1 Alleviates Enterotoxigenic Escherichia coli-Induced Adverse Effects in Piglets by Improving Host Immune Response and Anti-Oxidation Stress and Restoring Intestinal Integrity" @default.
• W3210245289 cites W1567029365 @default.
• W3210245289 cites W1568964113 @default.
• W3210245289 cites W1586392520 @default.
• W3210245289 cites W1910177016 @default.
• W3210245289 cites W1920101533 @default.
• W3210245289 cites W1967592636 @default.
• W3210245289 cites W1974738011 @default.
• W3210245289 cites W1976087136 @default.
• W3210245289 cites W1990898134 @default.
• W3210245289 cites W2015544673 @default.
• W3210245289 cites W2031003734 @default.
• W3210245289 cites W2064557077 @default.
• W3210245289 cites W2069143337 @default.
• W3210245289 cites W2081360912 @default.
• W3210245289 cites W2088534886 @default.
• W3210245289 cites W2105169496 @default.
• W3210245289 cites W2108943478 @default.
• W3210245289 cites W2110504024 @default.
• W3210245289 cites W2111075540 @default.
• W3210245289 cites W2117695549 @default.
• W3210245289 cites W2169982514 @default.
• W3210245289 cites W2264398093 @default.
• W3210245289 cites W2314329432 @default.
• W3210245289 cites W2339787264 @default.
• W3210245289 cites W241919742 @default.
• W3210245289 cites W2492531175 @default.
• W3210245289 cites W2562222733 @default.
• W3210245289 cites W2568001500 @default.
• W3210245289 cites W2626772985 @default.
• W3210245289 cites W2737372261 @default.
• W3210245289 cites W2770353641 @default.
• W3210245289 cites W2782525749 @default.
• W3210245289 cites W2804281796 @default.
• W3210245289 cites W2885148677 @default.
• W3210245289 cites W2896951691 @default.
• W3210245289 cites W2902016834 @default.
• W3210245289 cites W2986435328 @default.
• W3210245289 cites W3037119691 @default.
• W3210245289 cites W3048372430 @default.
• W3210245289 cites W3161268753 @default.
• W3210245289 cites W4230314843 @default.
• W3210245289 cites W4251245326 @default.
• W3210245289 cites W4300549900 @default.
• W3210245289 doi "https://doi.org/10.3389/fcimb.2021.724401" @default.
• W3210245289 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8594739" @default.
• W3210245289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34796123" @default.
• W3210245289 hasPublicationYear "2021" @default.
• W3210245289 type Work @default.
• W3210245289 sameAs 3210245289 @default.
• W3210245289 citedByCount "11" @default.
• W3210245289 countsByYear W32102452892022 @default.
• W3210245289 countsByYear W32102452892023 @default.
• W3210245289 crossrefType "journal-article" @default.
• W3210245289 hasAuthorship W3210245289A5010316221 @default.
• W3210245289 hasAuthorship W3210245289A5021364942 @default.
• W3210245289 hasAuthorship W3210245289A5022984104 @default.
• W3210245289 hasAuthorship W3210245289A5026470906 @default.
• W3210245289 hasAuthorship W3210245289A5044939434 @default.
• W3210245289 hasAuthorship W3210245289A5053204257 @default.
• W3210245289 hasAuthorship W3210245289A5056807970 @default.
• W3210245289 hasAuthorship W3210245289A5071869550 @default.
• W3210245289 hasAuthorship W3210245289A5073216396 @default.
• W3210245289 hasAuthorship W3210245289A5078348179 @default.
• W3210245289 hasAuthorship W3210245289A5078526337 @default.
• W3210245289 hasBestOaLocation W32102452891 @default.
• W3210245289 hasConcept C100544194 @default.
• W3210245289 hasConcept C104317684 @default.
• W3210245289 hasConcept C2776651480 @default.
• W3210245289 hasConcept C2777871010 @default.
• W3210245289 hasConcept C2780206646 @default.
• W3210245289 hasConcept C31903555 @default.
• W3210245289 hasConcept C547475151 @default.
• W3210245289 hasConcept C55493867 @default.
• W3210245289 hasConcept C66999527 @default.
• W3210245289 hasConcept C86803240 @default.
• W3210245289 hasConcept C89423630 @default.
• W3210245289 hasConceptScore W3210245289C100544194 @default.
• W3210245289 hasConceptScore W3210245289C104317684 @default.
• W3210245289 hasConceptScore W3210245289C2776651480 @default.
• W3210245289 hasConceptScore W3210245289C2777871010 @default.
• W3210245289 hasConceptScore W3210245289C2780206646 @default.
• W3210245289 hasConceptScore W3210245289C31903555 @default.
• W3210245289 hasConceptScore W3210245289C547475151 @default.
• W3210245289 hasConceptScore W3210245289C55493867 @default.

• next