Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210295893> ?p ?o ?g. }
- W3210295893 abstract "Chromosomal translocations are the main etiological factor of hematologic malignancies. These translocations are generally the consequence of aberrant DNA double-strand break (DSB) repair. DSBs arise either exogenously or endogenously in cells and are repaired by major pathways, including non-homologous end-joining (NHEJ), homologous recombination (HR), and other minor pathways such as alternative end-joining (A-EJ). Therefore, defective NHEJ, HR, or A-EJ pathways force hematopoietic cells toward tumorigenesis. As some components of these repair pathways are overactivated in various tumor entities, targeting these pathways in cancer cells can sensitize them, especially resistant clones, to radiation or chemotherapy agents. However, targeted therapy-based studies are currently underway in this area, and furtherly there are some biological pitfalls, clinical issues, and limitations related to these targeted therapies, which need to be considered. This review aimed to investigate the alteration of DNA repair elements of C-NHEJ and A-EJ in hematologic malignancies and evaluate the potential targeted therapies against these pathways." @default.
- W3210295893 created "2021-11-08" @default.
- W3210295893 creator A5010928656 @default.
- W3210295893 creator A5015485944 @default.
- W3210295893 creator A5023236506 @default.
- W3210295893 creator A5054224565 @default.
- W3210295893 creator A5059191079 @default.
- W3210295893 date "2021-11-03" @default.
- W3210295893 modified "2023-10-11" @default.
- W3210295893 title "Involvement of classic and alternative non-homologous end joining pathways in hematologic malignancies: targeting strategies for treatment" @default.
- W3210295893 cites W1491833199 @default.
- W3210295893 cites W1495123612 @default.
- W3210295893 cites W1525455704 @default.
- W3210295893 cites W1596534409 @default.
- W3210295893 cites W1660787335 @default.
- W3210295893 cites W1783508367 @default.
- W3210295893 cites W1787495625 @default.
- W3210295893 cites W1822429854 @default.
- W3210295893 cites W1827383047 @default.
- W3210295893 cites W1901755781 @default.
- W3210295893 cites W1964303064 @default.
- W3210295893 cites W1965057195 @default.
- W3210295893 cites W1969605996 @default.
- W3210295893 cites W1969656868 @default.
- W3210295893 cites W1972349989 @default.
- W3210295893 cites W1975913714 @default.
- W3210295893 cites W1981816841 @default.
- W3210295893 cites W1982362157 @default.
- W3210295893 cites W1982957001 @default.
- W3210295893 cites W1983993107 @default.
- W3210295893 cites W1984924974 @default.
- W3210295893 cites W1988542683 @default.
- W3210295893 cites W1989021153 @default.
- W3210295893 cites W1990026377 @default.
- W3210295893 cites W1990826225 @default.
- W3210295893 cites W1992688638 @default.
- W3210295893 cites W1992797151 @default.
- W3210295893 cites W1998864945 @default.
- W3210295893 cites W2000039654 @default.
- W3210295893 cites W2001418127 @default.
- W3210295893 cites W2001842525 @default.
- W3210295893 cites W2004167207 @default.
- W3210295893 cites W2005577286 @default.
- W3210295893 cites W2009254777 @default.
- W3210295893 cites W2011217489 @default.
- W3210295893 cites W2011345939 @default.
- W3210295893 cites W2011504410 @default.
- W3210295893 cites W2012838905 @default.
- W3210295893 cites W2013895149 @default.
- W3210295893 cites W2014022790 @default.
- W3210295893 cites W2015461126 @default.
- W3210295893 cites W2015594699 @default.
- W3210295893 cites W2016296894 @default.
- W3210295893 cites W2016719205 @default.
- W3210295893 cites W2016999017 @default.
- W3210295893 cites W2017358644 @default.
- W3210295893 cites W2022529631 @default.
- W3210295893 cites W2022873453 @default.
- W3210295893 cites W2023041438 @default.
- W3210295893 cites W2024254896 @default.
- W3210295893 cites W2026542497 @default.
- W3210295893 cites W2028296653 @default.
- W3210295893 cites W2029329407 @default.
- W3210295893 cites W2030257185 @default.
- W3210295893 cites W2032117887 @default.
- W3210295893 cites W2034814703 @default.
- W3210295893 cites W2035783471 @default.
- W3210295893 cites W2040680549 @default.
- W3210295893 cites W2043422521 @default.
- W3210295893 cites W2044020784 @default.
- W3210295893 cites W2045163964 @default.
- W3210295893 cites W2046916766 @default.
- W3210295893 cites W2047224624 @default.
- W3210295893 cites W2049464359 @default.
- W3210295893 cites W2050978400 @default.
- W3210295893 cites W2051523017 @default.
- W3210295893 cites W2052961175 @default.
- W3210295893 cites W2053311488 @default.
- W3210295893 cites W2055453653 @default.
- W3210295893 cites W2058259170 @default.
- W3210295893 cites W2059410730 @default.
- W3210295893 cites W2060312814 @default.
- W3210295893 cites W2061020520 @default.
- W3210295893 cites W2069700451 @default.
- W3210295893 cites W2070758111 @default.
- W3210295893 cites W2071115015 @default.
- W3210295893 cites W2072419001 @default.
- W3210295893 cites W2072758446 @default.
- W3210295893 cites W2078429149 @default.
- W3210295893 cites W2079874081 @default.
- W3210295893 cites W2080867823 @default.
- W3210295893 cites W2081383642 @default.
- W3210295893 cites W2083326500 @default.
- W3210295893 cites W2085391585 @default.
- W3210295893 cites W2088509899 @default.
- W3210295893 cites W2091279703 @default.
- W3210295893 cites W2100121711 @default.
- W3210295893 cites W2102794619 @default.
- W3210295893 cites W2104357153 @default.
- W3210295893 cites W2105762637 @default.