Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210328525> ?p ?o ?g. }
- W3210328525 endingPage "1340" @default.
- W3210328525 startingPage "1331" @default.
- W3210328525 abstract "Bladder cancer carries a poor prognosis and has proven resistance to chemotherapy. Pentacyclic Triterpenoid Acids (PTAs) are natural bioactive compounds that have a well-known impact on cancer research because of their cytotoxic and chemopreventive activities. This review focuses on bladder cancer which can no longer be successfully treated by DNA damaging drugs. Unlike most of the existing drugs against bladder cancer, PTAs are non-toxic to normal cells. Collecting findings from both in vitro and in vivo studies, it has been concluded that PTAs may serve as promising agents in future bladder cancer therapy. In this review, the roles of various PTAs in bladder cancer have been explored, and their mechanisms of action in the treatment of bladder cancer have been described. Specific PTAs have been shortlisted from each of the chief skeletons of pentacyclic triterpenoids, which could be effective against bladder cancer because of their mode of action. This review thereby throws light on the multi targets and mechanisms of PTAs, which are responsible for their selective anticancer effects and provides guidelines for further research and development of new natural antitumor compounds." @default.
- W3210328525 created "2021-11-08" @default.
- W3210328525 creator A5004068763 @default.
- W3210328525 creator A5011589978 @default.
- W3210328525 date "2022-05-01" @default.
- W3210328525 modified "2023-10-16" @default.
- W3210328525 title "Role of Pentacyclic Triterpenoid Acids in the Treatment of Bladder Cancer" @default.
- W3210328525 cites W1484056580 @default.
- W3210328525 cites W1526755650 @default.
- W3210328525 cites W1667321955 @default.
- W3210328525 cites W1937297206 @default.
- W3210328525 cites W1964166125 @default.
- W3210328525 cites W1964698686 @default.
- W3210328525 cites W1971844328 @default.
- W3210328525 cites W1974793320 @default.
- W3210328525 cites W1975120556 @default.
- W3210328525 cites W1975324295 @default.
- W3210328525 cites W1978742046 @default.
- W3210328525 cites W1980265915 @default.
- W3210328525 cites W1984727987 @default.
- W3210328525 cites W1989852705 @default.
- W3210328525 cites W1993492498 @default.
- W3210328525 cites W1993942242 @default.
- W3210328525 cites W1994941836 @default.
- W3210328525 cites W1997470573 @default.
- W3210328525 cites W2000178617 @default.
- W3210328525 cites W2000540236 @default.
- W3210328525 cites W2002240376 @default.
- W3210328525 cites W2010848572 @default.
- W3210328525 cites W2011510924 @default.
- W3210328525 cites W2016602233 @default.
- W3210328525 cites W2024885145 @default.
- W3210328525 cites W2026295263 @default.
- W3210328525 cites W2028277827 @default.
- W3210328525 cites W2028870439 @default.
- W3210328525 cites W2034206425 @default.
- W3210328525 cites W2035529103 @default.
- W3210328525 cites W2038765495 @default.
- W3210328525 cites W2039810057 @default.
- W3210328525 cites W2048154112 @default.
- W3210328525 cites W2049396254 @default.
- W3210328525 cites W2049538529 @default.
- W3210328525 cites W2051120695 @default.
- W3210328525 cites W2055782852 @default.
- W3210328525 cites W2061797905 @default.
- W3210328525 cites W2063822371 @default.
- W3210328525 cites W2064710674 @default.
- W3210328525 cites W2065423457 @default.
- W3210328525 cites W2068080664 @default.
- W3210328525 cites W2070326852 @default.
- W3210328525 cites W2071988200 @default.
- W3210328525 cites W2072151195 @default.
- W3210328525 cites W2080447135 @default.
- W3210328525 cites W2081145026 @default.
- W3210328525 cites W2082631974 @default.
- W3210328525 cites W2084075250 @default.
- W3210328525 cites W2089587489 @default.
- W3210328525 cites W2092161899 @default.
- W3210328525 cites W2093290099 @default.
- W3210328525 cites W2098441819 @default.
- W3210328525 cites W2103810253 @default.
- W3210328525 cites W2105452584 @default.
- W3210328525 cites W2108501192 @default.
- W3210328525 cites W2108746279 @default.
- W3210328525 cites W2109526314 @default.
- W3210328525 cites W2119515073 @default.
- W3210328525 cites W2120260995 @default.
- W3210328525 cites W2120630185 @default.
- W3210328525 cites W2123758767 @default.
- W3210328525 cites W2124186983 @default.
- W3210328525 cites W2133872514 @default.
- W3210328525 cites W2139294020 @default.
- W3210328525 cites W2139684004 @default.
- W3210328525 cites W2141999680 @default.
- W3210328525 cites W2142687511 @default.
- W3210328525 cites W2152793099 @default.
- W3210328525 cites W2158141891 @default.
- W3210328525 cites W2161603073 @default.
- W3210328525 cites W2169606127 @default.
- W3210328525 cites W2169616232 @default.
- W3210328525 cites W2170383516 @default.
- W3210328525 cites W2177584245 @default.
- W3210328525 cites W2181115948 @default.
- W3210328525 cites W2193066862 @default.
- W3210328525 cites W2196711563 @default.
- W3210328525 cites W2213763060 @default.
- W3210328525 cites W2247482695 @default.
- W3210328525 cites W2323377038 @default.
- W3210328525 cites W2473162054 @default.
- W3210328525 cites W2529595238 @default.
- W3210328525 cites W2595697424 @default.
- W3210328525 cites W2599436264 @default.
- W3210328525 cites W2615301036 @default.
- W3210328525 cites W2619733974 @default.
- W3210328525 cites W2620692547 @default.
- W3210328525 cites W2734631196 @default.
- W3210328525 cites W2734713150 @default.
- W3210328525 cites W273570570 @default.