FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210331473> ?p ?o ?g. }

• W3210331473 endingPage "D1407" @default.
• W3210331473 startingPage "D1398" @default.
• W3210331473 abstract "Drug discovery relies on the knowledge of not only drugs and targets, but also the comparative agents and targets. These include poor binders and non-binders for developing discovery tools, prodrugs for improved therapeutics, co-targets of therapeutic targets for multi-target strategies and off-target investigations, and the collective structure-activity and drug-likeness landscapes of enhanced drug feature. However, such valuable data are inadequately covered by the available databases. In this study, a major update of the Therapeutic Target Database, previously featured in NAR, was therefore introduced. This update includes (a) 34 861 poor binders and 12 683 non-binders of 1308 targets; (b) 534 prodrug-drug pairs for 121 targets; (c) 1127 co-targets of 672 targets regulated by 642 approved and 624 clinical trial drugs; (d) the collective structure-activity landscapes of 427 262 active agents of 1565 targets; (e) the profiles of drug-like properties of 33 598 agents of 1102 targets. Moreover, a variety of additional data and function are provided, which include the cross-links to the target structure in PDB and AlphaFold, 159 and 1658 newly emerged targets and drugs, and the advanced search function for multi-entry target sequences or drug structures. The database is accessible without login requirement at: https://idrblab.org/ttd/." @default.
• W3210331473 created "2021-11-08" @default.
• W3210331473 creator A5027440092 @default.
• W3210331473 creator A5045222033 @default.
• W3210331473 creator A5046274878 @default.
• W3210331473 creator A5061828914 @default.
• W3210331473 creator A5066802563 @default.
• W3210331473 creator A5076458955 @default.
• W3210331473 creator A5077700312 @default.
• W3210331473 creator A5079145492 @default.
• W3210331473 date "2021-10-28" @default.
• W3210331473 modified "2023-10-14" @default.
• W3210331473 title "Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents" @default.
• W3210331473 cites W1506311640 @default.
• W3210331473 cites W1808530289 @default.
• W3210331473 cites W1969301226 @default.
• W3210331473 cites W1981737096 @default.
• W3210331473 cites W1983330084 @default.
• W3210331473 cites W1988534836 @default.
• W3210331473 cites W2007436490 @default.
• W3210331473 cites W2018752930 @default.
• W3210331473 cites W2031295191 @default.
• W3210331473 cites W2034549041 @default.
• W3210331473 cites W2062458432 @default.
• W3210331473 cites W2069506489 @default.
• W3210331473 cites W2070789802 @default.
• W3210331473 cites W2082309242 @default.
• W3210331473 cites W2096525273 @default.
• W3210331473 cites W2098223336 @default.
• W3210331473 cites W2099308584 @default.
• W3210331473 cites W2102377211 @default.
• W3210331473 cites W2121895929 @default.
• W3210331473 cites W2135415614 @default.
• W3210331473 cites W2135732933 @default.
• W3210331473 cites W2148950790 @default.
• W3210331473 cites W2159887157 @default.
• W3210331473 cites W2160310346 @default.
• W3210331473 cites W2558217333 @default.
• W3210331473 cites W2560545237 @default.
• W3210331473 cites W2614935527 @default.
• W3210331473 cites W2765587792 @default.
• W3210331473 cites W2767891136 @default.
• W3210331473 cites W2782438044 @default.
• W3210331473 cites W2787229753 @default.
• W3210331473 cites W2801859295 @default.
• W3210331473 cites W2906033632 @default.
• W3210331473 cites W2909780007 @default.
• W3210331473 cites W2910249797 @default.
• W3210331473 cites W2913457010 @default.
• W3210331473 cites W2941880204 @default.
• W3210331473 cites W2942236604 @default.
• W3210331473 cites W2945303443 @default.
• W3210331473 cites W2953088968 @default.
• W3210331473 cites W2969980075 @default.
• W3210331473 cites W2970416468 @default.
• W3210331473 cites W2971690404 @default.
• W3210331473 cites W2972740870 @default.
• W3210331473 cites W2973039076 @default.
• W3210331473 cites W2980870427 @default.
• W3210331473 cites W2986115017 @default.
• W3210331473 cites W2986268970 @default.
• W3210331473 cites W2987179243 @default.
• W3210331473 cites W2987928072 @default.
• W3210331473 cites W2998462049 @default.
• W3210331473 cites W3001112033 @default.
• W3210331473 cites W3004758826 @default.
• W3210331473 cites W3010016408 @default.
• W3210331473 cites W3014163652 @default.
• W3210331473 cites W3018049863 @default.
• W3210331473 cites W3026590953 @default.
• W3210331473 cites W3033000020 @default.
• W3210331473 cites W3034196682 @default.
• W3210331473 cites W3037178617 @default.
• W3210331473 cites W3046986101 @default.
• W3210331473 cites W3087358630 @default.
• W3210331473 cites W3092072640 @default.
• W3210331473 cites W3095380161 @default.
• W3210331473 cites W3097145107 @default.
• W3210331473 cites W3103171309 @default.
• W3210331473 cites W3104537585 @default.
• W3210331473 cites W3110146947 @default.
• W3210331473 cites W3112376646 @default.
• W3210331473 cites W3112541839 @default.
• W3210331473 cites W3125539506 @default.
• W3210331473 cites W3134146005 @default.
• W3210331473 cites W3138130200 @default.
• W3210331473 cites W3154110316 @default.
• W3210331473 cites W3154885682 @default.
• W3210331473 cites W3163511095 @default.
• W3210331473 cites W3164710001 @default.
• W3210331473 cites W3177828909 @default.
• W3210331473 cites W3183475563 @default.
• W3210331473 cites W32337113 @default.
• W3210331473 cites W330953206 @default.
• W3210331473 cites W4205544245 @default.
• W3210331473 cites W4247001379 @default.
• W3210331473 doi "https://doi.org/10.1093/nar/gkab953" @default.
• W3210331473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34718717" @default.

• next