Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210347941> ?p ?o ?g. }
- W3210347941 abstract "Glioblastoma is the most malignant primary brain tumor and is still in need of effective medical treatment. We isolated patient-derived glioblastoma cells showing high GD2 antigen expression representing a potential target for CAR T strategy. Data highlighted a robust GD2 CAR antitumor potential in 2D and 3D glioblastoma models associated with a significant and CAR T-restricted increase of selected cytokines. Interestingly, immunosuppressant TGF β1, expressed in all co-cultures, did not influence antitumor activity. The orthotopic NOD/SCID models using primary glioblastoma cells reproduced human histopathological features. Considering still-conflicting data on the delivery route for targeting brain tumors, we compared intracerebral versus intravenous CAR T injections. We report that the intracerebral route significantly increased the length of survival time in a dose-dependent manner, without any side effects. Collectively, the proposed anti-GD2 CAR can counteract human glioblastoma potentially opening a new therapeutic option for a still incurable cancer." @default.
- W3210347941 created "2021-11-08" @default.
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- W3210347941 date "2021-10-27" @default.
- W3210347941 modified "2023-09-30" @default.
- W3210347941 title "GD2 CAR T cells against human glioblastoma" @default.
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- W3210347941 doi "https://doi.org/10.1038/s41698-021-00233-9" @default.
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