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- W3210357815 endingPage "5353" @default.
- W3210357815 startingPage "5353" @default.
- W3210357815 abstract "Somatic DNA hypomethylation and aneuploidy are hallmarks of cancer, and there is evidence for a causal relationship between them in knockout mice but not in human cancer. The non-mobile pericentromeric repetitive elements SST1 are hypomethylated in about 17% of human colorectal cancers (CRC) with some 5-7% exhibiting strong age-independent demethylation. We studied the frequency of genome doubling, a common event in solid tumors linked to aneuploidy, in randomly selected single cell clones of near-diploid LS174T human CRC cells differing in their level of SST1 demethylation. Near-diploid LS174T cells underwent frequent genome-doubling events generating near-tetraploid clones with lower levels of SST1 methylation. In primary CRC, strong SST1 hypomethylation was significantly associated with global genomic hypomethylation and mutations in TP53. This work uncovers the association of the naturally occurring demethylation of the SST1 pericentromeric repeat with the onset of spontaneous tetraploidization in human CRC cells in culture and with TP53 mutations in primary CRCs. Altogether, our findings provide further support for an oncogenic pathway linking somatic hypomethylation and genetic copy number alterations in a subset of human CRC." @default.
- W3210357815 created "2021-11-08" @default.
- W3210357815 creator A5034115267 @default.
- W3210357815 creator A5035639497 @default.
- W3210357815 creator A5042537187 @default.
- W3210357815 creator A5050895417 @default.
- W3210357815 creator A5057121219 @default.
- W3210357815 creator A5062956659 @default.
- W3210357815 creator A5081495796 @default.
- W3210357815 date "2021-10-26" @default.
- W3210357815 modified "2023-10-09" @default.
- W3210357815 title "Somatic Hypomethylation of Pericentromeric SST1 Repeats and Tetraploidization in Human Colorectal Cancer Cells" @default.
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