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• W3210361302 endingPage "1865" @default.
• W3210361302 startingPage "1858" @default.
• W3210361302 abstract "The necessity of new drugs with special attention for the therapy of cancer is increasing each day. Despite their properties, alpha therapeutic radiopharmaceuticals, especially based on the use of radium (223Ra) are good choices, due to the highest and differential cytotoxicity, low adverse effects, and higher bioaccumulation on tumor sites. The use of graphene quantum dots as the carrier for 223Ra is a promising approach since graphene quantum dots has low toxicity, high biocompatibility, and adequate size for tumor penetration. In this study, we developed, characterized, radiolabeled with 223Ra, and evaluated in vitro and in vivo graphene quantum dots radiolabeled with radium (223Ra) for bone cancer. The results showed that 223Ra is incorporated into the graphene quantum dot following the Fajans-Paneth-Hahn Law. The cell viability showed a potent effect on osteosarcoma cells (MG63 and SAOS2) but a lower effect in normal fibroblast cells (hFB), corroborating the preferential targeting. Also, the results showed a more prominent effect on MG63 than SAOS2 cells, corroborating the targeting for more undifferentiated cells. The in vivo results demonstrated a renal excretion, associated with fecal excretion and accumulation in bone. The results corroborate the efficacy of 223RaGQDs and open new perspectives for the use of use 223RaGQDs, in several other diseases." @default.
• W3210361302 created "2021-11-08" @default.
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• W3210361302 date "2021-09-01" @default.
• W3210361302 modified "2023-09-25" @default.
• W3210361302 title "Graphene Quantum Dots for Molecular Radiotherapy: Radiolabeled Graphene Quantum Dots with Radium (²²³Ra) Showed Potent Effect Against Bone Cancer" @default.
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• W3210361302 doi "https://doi.org/10.1166/jbn.2021.3150" @default.
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• W3210361302 hasPublicationYear "2021" @default.
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