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• W3210361476 abstract "Phleboviruses (order Bunyavirales, family Phenuiviridae) are globally emerging arboviruses with a wide spectrum of virulence. Sandfly fever Sicilian virus (SFSV) is one of the most ubiquitous members of the genus Phlebovirus and associated with a self-limited, incapacitating febrile disease in travellers and military troops. The phleboviral NSs protein is an established virulence factor, acting as antagonist of the antiviral interferon (IFN) system. Consistently, we previously reported that SFSV NSs targets the induction of IFN mRNA synthesis by specifically binding to the DNA-binding domain of the IFN transcription factor IRF3. Here, we further characterized the effect of SFSV and its NSs towards IFN induction, and evaluated its potential to affect the downstream IFN-stimulated signalling and the subsequent transactivation of antiviral interferon-stimulated genes (ISGs). We found that SFSV dampened, but did not entirely abolish type I and type III IFN induction. Furthermore, SFSV NSs did not affect IFN signalling, resulting in substantial ISG expression in infected cells. Hence, although SFSV targets IRF3 to reduce IFN induction, it is not capable of entirely disarming the IFN system in the presence of high basal IRF3 and/or IRF7 levels, and we speculate that this significantly contributes to its low level of virulence." @default.
• W3210361476 created "2021-11-08" @default.
• W3210361476 creator A5073066225 @default.
• W3210361476 creator A5088808959 @default.
• W3210361476 date "2021-11-02" @default.
• W3210361476 modified "2023-09-23" @default.
• W3210361476 title "NSs of the mildly virulent sandfly fever Sicilian virus is unable to inhibit interferon signaling and upregulation of interferon-stimulated genes" @default.
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• W3210361476 cites W1967532109 @default.
• W3210361476 cites W1978148605 @default.
• W3210361476 cites W1996116018 @default.
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• W3210361476 doi "https://doi.org/10.1099/jgv.0.001676" @default.
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• W3210361476 hasPublicationYear "2021" @default.
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