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• W3210363771 endingPage "1152" @default.
• W3210363771 startingPage "1137" @default.
• W3210363771 abstract "Abstract Background Kdm6b, a specific histone 3 lysine 27 (H3K27) demethylase, has been reported to be implicated in a variety of developmental processes including cell differentiation and cell fate determination and multiple organogenesis. Here, we regulated the transcript level of kdm6bb to study the potential role in controlling the hearing organ development of zebrafish. Methods A morpholino antisense oligonucleotide (MO) strategy was used to induce Kdm6b deficiency; immunohistochemical staining and in situ hybridization analysis were conducted to figure out the morphologic alterations and embryonic mechanisms. Results Kdm6bb is expressed in the primordium and neuromasts at the early stage of zebrafish embryogenesis, suggesting a potential function of Kdm6b in the development of mechanosensory organs. Knockdown of kdm6bb severely influences the cell migration and proliferation in posterior lateral line primordium, abates the number of neuromasts along the trunk, and mRNA-mediated rescue test can partially renew the neuromasts. Loss of kdm6bb might be related to aberrant expressions of chemokine genes encompassing cxcl12a and cxcr4b/cxcr7b in the migrating primordium. Moreover, inhibition of kdm6bb reduces the expression of genes in Fgf signaling pathway, while it increases the axin2 and lef1 expression level of Wnt/β-catenin signaling during the migrating stage. Conclusions Collectively, our results revealed that Kdm6b plays an essential role in guiding the migration of primordium and in regulating the deposition of zebrafish neuromasts by mediating the gene expression of chemokines and Wnt and Fgf signaling pathway. Since histone methylation and demethylation are reversible, targeting Kdm6b may present as a novel therapeutic regimen for hearing disorders." @default.
• W3210363771 created "2021-11-08" @default.
• W3210363771 creator A5016898751 @default.
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• W3210363771 date "2021-10-29" @default.
• W3210363771 modified "2023-10-18" @default.
• W3210363771 title "The H3K27 demethylase controls the lateral line embryogenesis of zebrafish" @default.
• W3210363771 cites W1963665032 @default.
• W3210363771 cites W1968802624 @default.
• W3210363771 cites W1970592702 @default.
• W3210363771 cites W1970840610 @default.
• W3210363771 cites W1974069185 @default.
• W3210363771 cites W1980098393 @default.
• W3210363771 cites W1985122731 @default.
• W3210363771 cites W1988589306 @default.
• W3210363771 cites W1995371403 @default.
• W3210363771 cites W1996846221 @default.
• W3210363771 cites W2004608668 @default.
• W3210363771 cites W2008735740 @default.
• W3210363771 cites W2010516412 @default.
• W3210363771 cites W2010755806 @default.
• W3210363771 cites W2018905452 @default.
• W3210363771 cites W2019025595 @default.
• W3210363771 cites W2025313234 @default.
• W3210363771 cites W2027677131 @default.
• W3210363771 cites W2032368486 @default.
• W3210363771 cites W2037540667 @default.
• W3210363771 cites W2037839294 @default.
• W3210363771 cites W2042581231 @default.
• W3210363771 cites W2054378694 @default.
• W3210363771 cites W2062927905 @default.
• W3210363771 cites W2072665920 @default.
• W3210363771 cites W2072755258 @default.
• W3210363771 cites W2072859865 @default.
• W3210363771 cites W2080585376 @default.
• W3210363771 cites W2083231860 @default.
• W3210363771 cites W2084397828 @default.
• W3210363771 cites W2085878806 @default.
• W3210363771 cites W2086554513 @default.
• W3210363771 cites W2091193918 @default.
• W3210363771 cites W2091744502 @default.
• W3210363771 cites W2093890422 @default.
• W3210363771 cites W2096251733 @default.
• W3210363771 cites W2098238806 @default.
• W3210363771 cites W2101912958 @default.
• W3210363771 cites W2116929458 @default.
• W3210363771 cites W2124994200 @default.
• W3210363771 cites W2125349610 @default.
• W3210363771 cites W2126445725 @default.
• W3210363771 cites W2133536768 @default.
• W3210363771 cites W2135498007 @default.
• W3210363771 cites W2142750959 @default.
• W3210363771 cites W2143764351 @default.
• W3210363771 cites W2147310171 @default.
• W3210363771 cites W2147821804 @default.
• W3210363771 cites W2150044044 @default.
• W3210363771 cites W2171102198 @default.
• W3210363771 cites W2172290898 @default.
• W3210363771 cites W2185909429 @default.
• W3210363771 cites W2252418997 @default.
• W3210363771 cites W2320983896 @default.
• W3210363771 cites W2398957011 @default.
• W3210363771 cites W2410285656 @default.
• W3210363771 cites W2549992612 @default.
• W3210363771 cites W2597078390 @default.
• W3210363771 cites W2601144754 @default.
• W3210363771 cites W2601682232 @default.
• W3210363771 cites W2612084614 @default.
• W3210363771 cites W2797069917 @default.
• W3210363771 cites W2800391176 @default.
• W3210363771 cites W2892055647 @default.
• W3210363771 cites W2895714451 @default.
• W3210363771 cites W2906805386 @default.
• W3210363771 cites W2907628944 @default.
• W3210363771 cites W2933260868 @default.
• W3210363771 cites W2989840253 @default.
• W3210363771 cites W2994611337 @default.
• W3210363771 cites W3001655293 @default.
• W3210363771 cites W3016417719 @default.
• W3210363771 cites W3042658708 @default.
• W3210363771 cites W404578216 @default.
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• W3210363771 doi "https://doi.org/10.1007/s10565-021-09669-y" @default.
• W3210363771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34716527" @default.
• W3210363771 hasPublicationYear "2021" @default.
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