Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210366260> ?p ?o ?g. }
- W3210366260 endingPage "206" @default.
- W3210366260 startingPage "198" @default.
- W3210366260 abstract "We evaluated long-term outcome in 40 patients with MDS or AML, transplanted from related or unrelated donors following conditioning with targeted busulfan (Bu, over 4 days), fludarabine (Flu, 120 [n = 23] or 250 [n = 17] mg/m2) and thymoglobulin (THY). Compared to 95 patients conditioned with Bu/Cyclophosphamide (Cy) without THY, BuFluTHY-conditioned patients had lower rates of chronic graft-vs.-host disease (GVHD). Adjusted hazard ratios (HR) for BuFlu(120)THY and BuFlu(250)THY-conditioned patients were 1.60 (95% confidence interval (CI) 0.66-3.86) and 1.87 (0.68-5.11), respectively, for relapse; 0.77 (0.30-1.99) and 1.32 (0.54-3.23) for non-relapse mortality; 0.81 (0.42-1.57) and 1.38 (0.72-2.57) for overall mortality; and 0.78 (0.30-2.05) and 1.62 (0.63-4.41) for relapse or death (failure for relapse-free survival). At one year, 45% of BuFlu(120 or 250)THY-conditioned patients had mixed CD3+ chimerism compared to 0% with BuCy (p < 0.0001). None of 7 patients with long-term mixed chimerism had chronic GVHD; two relapsed, five remained stable mixed chimeras. THY is effective in reducing chronic GVHD, and long-term mixed T-cell chimerism can be compatible with relapse-free survival. However, Thy may also be associated with an increased risk of relapse and, dose-dependent, with non-relapse mortality." @default.
- W3210366260 created "2021-11-08" @default.
- W3210366260 creator A5010962133 @default.
- W3210366260 creator A5011099910 @default.
- W3210366260 creator A5011326866 @default.
- W3210366260 creator A5016644532 @default.
- W3210366260 creator A5023949296 @default.
- W3210366260 creator A5024123937 @default.
- W3210366260 creator A5036641601 @default.
- W3210366260 creator A5037538071 @default.
- W3210366260 creator A5038311224 @default.
- W3210366260 creator A5052927157 @default.
- W3210366260 creator A5056405520 @default.
- W3210366260 creator A5059063645 @default.
- W3210366260 creator A5070467855 @default.
- W3210366260 creator A5080637625 @default.
- W3210366260 date "2021-11-05" @default.
- W3210366260 modified "2023-10-09" @default.
- W3210366260 title "Long-term survival with mixed chimerism in patients with AML and MDS transplanted after conditioning with targeted busulfan, fludarabine, and thymoglobulin" @default.
- W3210366260 cites W132394059 @default.
- W3210366260 cites W1491993932 @default.
- W3210366260 cites W1508187469 @default.
- W3210366260 cites W169590802 @default.
- W3210366260 cites W1965458218 @default.
- W3210366260 cites W1973617793 @default.
- W3210366260 cites W1977384601 @default.
- W3210366260 cites W1979146644 @default.
- W3210366260 cites W1994119960 @default.
- W3210366260 cites W1996893745 @default.
- W3210366260 cites W2012094734 @default.
- W3210366260 cites W2017724201 @default.
- W3210366260 cites W2018832820 @default.
- W3210366260 cites W2020347902 @default.
- W3210366260 cites W2023703038 @default.
- W3210366260 cites W2029754852 @default.
- W3210366260 cites W2034396882 @default.
- W3210366260 cites W2037596769 @default.
- W3210366260 cites W2039334806 @default.
- W3210366260 cites W2055313377 @default.
- W3210366260 cites W2059199394 @default.
- W3210366260 cites W2061119990 @default.
- W3210366260 cites W2063692775 @default.
- W3210366260 cites W2066714409 @default.
- W3210366260 cites W2067831127 @default.
- W3210366260 cites W2069377065 @default.
- W3210366260 cites W2079941902 @default.
- W3210366260 cites W2094213721 @default.
- W3210366260 cites W2107611068 @default.
- W3210366260 cites W2111395979 @default.
- W3210366260 cites W2114072750 @default.
- W3210366260 cites W2120504920 @default.
- W3210366260 cites W2139891677 @default.
- W3210366260 cites W2143258371 @default.
- W3210366260 cites W2143572023 @default.
- W3210366260 cites W2144718251 @default.
- W3210366260 cites W2146910383 @default.
- W3210366260 cites W2155722011 @default.
- W3210366260 cites W2162927689 @default.
- W3210366260 cites W2164885965 @default.
- W3210366260 cites W2178445865 @default.
- W3210366260 cites W2209448786 @default.
- W3210366260 cites W2209664554 @default.
- W3210366260 cites W2211551921 @default.
- W3210366260 cites W2233354089 @default.
- W3210366260 cites W2258328504 @default.
- W3210366260 cites W2766752961 @default.
- W3210366260 cites W2900453381 @default.
- W3210366260 cites W2969519229 @default.
- W3210366260 cites W2999004039 @default.
- W3210366260 cites W3001557001 @default.
- W3210366260 cites W3001829780 @default.
- W3210366260 cites W3043272172 @default.
- W3210366260 cites W3157387440 @default.
- W3210366260 doi "https://doi.org/10.1038/s41409-021-01518-0" @default.
- W3210366260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34741096" @default.
- W3210366260 hasPublicationYear "2021" @default.
- W3210366260 type Work @default.
- W3210366260 sameAs 3210366260 @default.
- W3210366260 citedByCount "2" @default.
- W3210366260 countsByYear W32103662602022 @default.
- W3210366260 countsByYear W32103662602023 @default.
- W3210366260 crossrefType "journal-article" @default.
- W3210366260 hasAuthorship W3210366260A5010962133 @default.
- W3210366260 hasAuthorship W3210366260A5011099910 @default.
- W3210366260 hasAuthorship W3210366260A5011326866 @default.
- W3210366260 hasAuthorship W3210366260A5016644532 @default.
- W3210366260 hasAuthorship W3210366260A5023949296 @default.
- W3210366260 hasAuthorship W3210366260A5024123937 @default.
- W3210366260 hasAuthorship W3210366260A5036641601 @default.
- W3210366260 hasAuthorship W3210366260A5037538071 @default.
- W3210366260 hasAuthorship W3210366260A5038311224 @default.
- W3210366260 hasAuthorship W3210366260A5052927157 @default.
- W3210366260 hasAuthorship W3210366260A5056405520 @default.
- W3210366260 hasAuthorship W3210366260A5059063645 @default.
- W3210366260 hasAuthorship W3210366260A5070467855 @default.
- W3210366260 hasAuthorship W3210366260A5080637625 @default.
- W3210366260 hasBestOaLocation W32103662602 @default.
- W3210366260 hasConcept C126322002 @default.