Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210367488> ?p ?o ?g. }
- W3210367488 endingPage "e505" @default.
- W3210367488 startingPage "e497" @default.
- W3210367488 abstract "Two-dimensional (2D) morphometric measures have been previously used to diagnose Chiari I malformation (CMI) and distinguish patients from healthy subjects. There is, however, a paucity of literature regarding whether morphometric differences exist across the range of CMI disease severity. We evaluated whether 2D morphometrics demonstrate significant changes across standardized grades of CMI severity in adults. This retrospective observational study comprised 76 patients with symptomatic CMI with or without syringomyelia. Patients matched for age, sex, and body mass index were selected from each of the 3 severity grades of the Chiari Severity Index (CSI). The study used 17 2D craniocervical and posterior fossa morphometric variables that were previously found to differentiate patients with CMI from healthy subjects. The measurements were performed on midsagittal T1-weighted magnetic resonance imaging sequences using 2 custom in-house software tools, MorphPro and CerePro, and compared across CSI grades. Analysis of variance showed that none of the 17 morphometric variables were significantly different across the 3 CSI grades (P > 0.003). Bayes factor 10 scores ranged from 0.11 to 0.82. Of variables, 9 had Bayes factor 10 scores between 0.10 and 0.30, while 8 had scores between 0.30 and 1. None of the Bayes factor 10 scores provided support for the alternative hypothesis that the morphometric measures differed across the CSI grades. Our study indicated that 2D morphometrics are not reflective of CMI disease severity as indicated by the CSI grading system. The findings of our study support the need for further investigation into whether non-2D morphometric variables can be used as markers of disease severity." @default.
- W3210367488 created "2021-11-08" @default.
- W3210367488 creator A5022196954 @default.
- W3210367488 creator A5022460652 @default.
- W3210367488 creator A5034259025 @default.
- W3210367488 creator A5034860275 @default.
- W3210367488 creator A5037462628 @default.
- W3210367488 creator A5046041622 @default.
- W3210367488 creator A5053888939 @default.
- W3210367488 creator A5076387267 @default.
- W3210367488 creator A5085190872 @default.
- W3210367488 date "2022-01-01" @default.
- W3210367488 modified "2023-10-12" @default.
- W3210367488 title "Are Two-Dimensional Morphometric Measures Reflective of Disease Severity in Adult Chiari I Malformation?" @default.
- W3210367488 cites W1528224305 @default.
- W3210367488 cites W1987611657 @default.
- W3210367488 cites W1988790445 @default.
- W3210367488 cites W2009386516 @default.
- W3210367488 cites W2016838126 @default.
- W3210367488 cites W2031789283 @default.
- W3210367488 cites W2054957788 @default.
- W3210367488 cites W2072374570 @default.
- W3210367488 cites W2083977203 @default.
- W3210367488 cites W2090524462 @default.
- W3210367488 cites W2095783605 @default.
- W3210367488 cites W2101910462 @default.
- W3210367488 cites W2119861371 @default.
- W3210367488 cites W2126602013 @default.
- W3210367488 cites W2167012733 @default.
- W3210367488 cites W2169345087 @default.
- W3210367488 cites W2217323528 @default.
- W3210367488 cites W2254522477 @default.
- W3210367488 cites W2267105568 @default.
- W3210367488 cites W2488620203 @default.
- W3210367488 cites W2508202850 @default.
- W3210367488 cites W2579962939 @default.
- W3210367488 cites W2605982445 @default.
- W3210367488 cites W2745613018 @default.
- W3210367488 cites W2765616695 @default.
- W3210367488 cites W2766405473 @default.
- W3210367488 cites W2767258514 @default.
- W3210367488 cites W2767945186 @default.
- W3210367488 cites W2785319308 @default.
- W3210367488 cites W2801920428 @default.
- W3210367488 cites W2889652134 @default.
- W3210367488 cites W2905239343 @default.
- W3210367488 cites W2945426691 @default.
- W3210367488 cites W2950745779 @default.
- W3210367488 cites W2952705141 @default.
- W3210367488 cites W2958620370 @default.
- W3210367488 cites W2995278953 @default.
- W3210367488 cites W3015394944 @default.
- W3210367488 cites W3023356948 @default.
- W3210367488 cites W3025308081 @default.
- W3210367488 cites W3026847834 @default.
- W3210367488 cites W3038041175 @default.
- W3210367488 cites W3082984271 @default.
- W3210367488 cites W3091779368 @default.
- W3210367488 cites W3092821678 @default.
- W3210367488 cites W3118970951 @default.
- W3210367488 doi "https://doi.org/10.1016/j.wneu.2021.10.138" @default.
- W3210367488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34710575" @default.
- W3210367488 hasPublicationYear "2022" @default.
- W3210367488 type Work @default.
- W3210367488 sameAs 3210367488 @default.
- W3210367488 citedByCount "4" @default.
- W3210367488 countsByYear W32103674882022 @default.
- W3210367488 countsByYear W32103674882023 @default.
- W3210367488 crossrefType "journal-article" @default.
- W3210367488 hasAuthorship W3210367488A5022196954 @default.
- W3210367488 hasAuthorship W3210367488A5022460652 @default.
- W3210367488 hasAuthorship W3210367488A5034259025 @default.
- W3210367488 hasAuthorship W3210367488A5034860275 @default.
- W3210367488 hasAuthorship W3210367488A5037462628 @default.
- W3210367488 hasAuthorship W3210367488A5046041622 @default.
- W3210367488 hasAuthorship W3210367488A5053888939 @default.
- W3210367488 hasAuthorship W3210367488A5076387267 @default.
- W3210367488 hasAuthorship W3210367488A5085190872 @default.
- W3210367488 hasBestOaLocation W32103674881 @default.
- W3210367488 hasConcept C126322002 @default.
- W3210367488 hasConcept C126838900 @default.
- W3210367488 hasConcept C127413603 @default.
- W3210367488 hasConcept C143409427 @default.
- W3210367488 hasConcept C147176958 @default.
- W3210367488 hasConcept C23131810 @default.
- W3210367488 hasConcept C2777286243 @default.
- W3210367488 hasConcept C2777836068 @default.
- W3210367488 hasConcept C2780221984 @default.
- W3210367488 hasConcept C2781149351 @default.
- W3210367488 hasConcept C30036603 @default.
- W3210367488 hasConcept C71924100 @default.
- W3210367488 hasConcept C99476002 @default.
- W3210367488 hasConceptScore W3210367488C126322002 @default.
- W3210367488 hasConceptScore W3210367488C126838900 @default.
- W3210367488 hasConceptScore W3210367488C127413603 @default.
- W3210367488 hasConceptScore W3210367488C143409427 @default.
- W3210367488 hasConceptScore W3210367488C147176958 @default.
- W3210367488 hasConceptScore W3210367488C23131810 @default.