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• W3210367609 abstract "Objectives The dysregulation of circular RNAs (circRNAs) is implicated in the progression of various cancers. This study was aimed at expounding the role and mechanism of hsa_circ_0002141 in the OSCC progression. Materials and Methods Circ_0002141 expression was examined in 52 pairs of OSCC tissues and matched adjacent tissue samples by quantitative real-time polymerase chain reaction (qRT-PCR) assay. After circ_0002141 was overexpressed or knocked down in OSCC cell lines, cell counting kit-8 (CCK-8) assay, Transwell assay, flow cytometry, and Western blotting were conducted to detect the changes in the growth, migration, invasion and apoptosis of OSCC cells. Western blot assay, qRT-PCR and dual-luciferase reporter assay were performed to clarify the interplay among circ_0002141, miR-1231, and epidermal growth factor receptor (EGFR). Results Circ_0002141 expression was significantly upregulated in OSCC tissues and cell lines. Circ_0002141 overexpression markedly promoted the proliferation, migration, and invasion of OSCC cells whereas reduced the apoptotic of OSCC cells. Also, circ_0002141 knockdown suppressed the malignant characteristics of OSCC cells. EGFR was validated as the target of miR-1231. Besides, circ_0002141 could sponge miR-1231 and upregulate EGFR expression in OSCC cells. Conclusion Circ_0002141/miR-1231/EGFR axis is involved in the progression of OSCC." @default.
• W3210367609 created "2021-11-08" @default.
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• W3210367609 date "2022-01-18" @default.
• W3210367609 modified "2023-09-23" @default.
• W3210367609 title "Upregulated circ_0002141 facilitates oral squamous cell carcinoma progression via the miR‐1231/EGFR axis" @default.
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• W3210367609 doi "https://doi.org/10.1111/odi.14070" @default.
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