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- W3210432871 abstract "Compared to the biological world’s rich chemistry for functionalizing carbon, enzymatic transformations of the heavier homologue silicon are rare. We report that a wild-type cytochrome P450 monooxygenase (P450 BM3 from Bacillus megaterium, CYP102A1) has promiscuous activity for oxidation of hydrosilanes to make silanols. Directed evolution enhanced this non-native activity and created a highly efficient catalyst for selective silane oxidation under mild conditions with oxygen as terminal oxidant. The evolved enzyme does not touch C–H bonds also present in the silane substrates, nor does this biotransformation lead to disiloxane formation, a common problem in silanol syntheses. Computational studies reveal that catalysis proceeds through hydrogen atom abstraction followed by radical rebound, as observed in the P450’s native C–H hydroxylation mechanism. Enzymatic silane oxidation now extends Nature’s already impressive catalytic repertoire." @default.
- W3210432871 created "2021-11-08" @default.
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- W3210432871 date "2020-03-18" @default.
- W3210432871 modified "2023-09-27" @default.
- W3210432871 title "Selective Enzymatic Oxidation of Silanes to Silanols" @default.
- W3210432871 doi "https://doi.org/10.26434/chemrxiv.11996379.v1" @default.
- W3210432871 hasPublicationYear "2020" @default.
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