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- W3210459942 abstract "Breast cancer, the most frequent cancer diagnosed among females, is associated with a high mortality rate worldwide. Alterations in the microbiota have been linked with breast cancer development, suggesting the possibility of discovering disease biomarkers. Metabolomics has emerged as an advanced promising analytical approach for profiling metabolic features associated with breast cancer subtypes, disease progression, and response to treatment. The microenvironment compromises non-cancerous cells such as fibroblasts and influences cancer progression with apparent phenotypes. This review discusses the role of metabolomics in studying metabolic dysregulation in breast cancer caused by the effect of the tumor microenvironment on multiple cells such as immune cells, fibroblasts, adipocytes, etc. Breast tumor cells have a unique metabolic profile through the elevation of glycolysis and the tricarboxylic acid cycle metabolism. This metabolic profile is highly sensitive to microbiota activity in the breast tissue microenvironment. Metabolomics shows great potential as a tool for monitoring metabolic dysregulation in tissue and associating the findings with microbiome expression." @default.
- W3210459942 created "2021-11-08" @default.
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- W3210459942 date "2021-11-04" @default.
- W3210459942 modified "2023-10-17" @default.
- W3210459942 title "Metabolomics-Microbiome Crosstalk in the Breast Cancer Microenvironment" @default.
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- W3210459942 doi "https://doi.org/10.3390/metabo11110758" @default.
- W3210459942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8619468" @default.
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- W3210459942 hasPublicationYear "2021" @default.
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