Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210494287> ?p ?o ?g. }
- W3210494287 abstract "The mechanisms triggering the transition from in situ tumors to invasive carcinomas are poorly understood. The process involves breaching tumor-containing basement membranes (BM) and cancer cell invasion into the tumor stroma. Myosin-X (MYO10) is a filopodia-inducing protein frequently overexpressed in metastatic breast cancer. Here, we investigated the contribution of MYO10 to invasive breast tumor progression. We found that downregulation of MYO10 expression reduces breast cancer cell protrusions and migration in vitro . In addition, it attenuates protrusive activity and cell motility in early-stage breast cancer xenografts, which is in line with MYO10’s established pro-invasive function. However, MYO10 depletion also promoted the local dispersal of increasingly basal-like tumor cells into the tumor stroma in vivo , resembling the transition from in situ to invasive tumors. MYO10-depleted tumors exhibited compromised BM structures, which correlated with increased mRNA expression but the reduced assembly of BM proteins surrounding the xenograft. Furthermore, MYO10-depleted 3D spheroids were defective in extracellular matrix (ECM) assembly around the spheroids, indicating a functional role for MYO10 in ECM deposition. Altogether, our data support a model where tumor cell protrusive activity, induced by MYO10, contributes to anti-invasive ECM organization at the in situ stages of breast cancer but promotes cell motility in advanced invasive breast cancer." @default.
- W3210494287 created "2021-11-08" @default.
- W3210494287 creator A5002186647 @default.
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- W3210494287 creator A5069911296 @default.
- W3210494287 creator A5089278623 @default.
- W3210494287 date "2021-10-22" @default.
- W3210494287 modified "2023-09-27" @default.
- W3210494287 title "Myosin-X-dependent assembly of the extracellular matrix limits breast cancer invasion" @default.
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