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• W3210512424 abstract "The expanding use of next generation sequencing (NGS) in solid tumors has resulted in a paradigm shift from empiric use of cytotoxic therapies to use of targeted genotype-directed therapy. Among gynecologic malignancies, description of molecular profiles via The Cancer Genome Atlas (TCGA) demonstrates a number of genes with frequent aberrations across these tumors [ 1 The Cancer Genome Atlas Research Network Integrated genomic analyses of ovarian carcinoma. Nature. 2011; 474: 609-615 Crossref PubMed Scopus (5094) Google Scholar , 2 Cancer Genome Atlas Research Network Kandoth C. Schultz N. Cherniack A.D. et al. Integrated genomic characterization of endometrial carcinoma. Nature. 2013; 497: 67-73 Crossref PubMed Scopus (2685) Google Scholar , 3 Ojesina A.I. Lichtenstein L. Freeman S.S. et al. Landscape of genomic alterations in cervical carcinomas. Nature. 2014; 506: 371-3754 Crossref PubMed Scopus (530) Google Scholar ]. However, the actionability of these mutations and efficacy of therapies associated with them vary greatly by agent and tumor type. Thus, when compared with other solid tumors, gynecologic cancers have had relatively fewer genotype-specific therapeutic approvals by the FDA." @default.
• W3210512424 created "2021-11-08" @default.
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• W3210512424 date "2021-11-01" @default.
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• W3210512424 title "Next generation sequencing for gynecologic malignancy: Promise and potential pitfalls" @default.
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• W3210512424 doi "https://doi.org/10.1016/j.ygyno.2021.10.005" @default.
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