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- W3210568900 abstract "Aminoacyl-tRNA synthetases (aaRSs) are essential and ubiquitous enzymes catalyzing formation of aminoacyl- tRNAs (aa-tRNAs) during protein synthesis. However, aaRSs are not limited to aa-tRNAs formation. Indeed, they evolved to form multl-protein complexes that acquired additional functions. S. cerevisiae contains the simplest eukaryotic multi-synthetase complex which is formed by the association of methionyl-tRNA synthetase (MetRS) and glutamyl-tRNA synthetase (GluRS) to the cytosolic anchoring protein Arc1.This complex (named AME) is highly dynamic depending on the nutritional conditions that the cells are facing, and the two associated aaRSs harbor additional functions that are essential for cell survival. In this PhD thesis, I have studied three different aspect of theyeast MetRS: (i) I created a new bifluorescent reporter to quantify endogenous mismethionylation mediated by the yeast MetRS. I also (ii) characterized a new truncated yeast MetRS isoform produced in vivo, and (iii) I analysed the relative importance of Arc1for cell surviving during the diauxic shift from fermentation to respiration." @default.
- W3210568900 created "2021-11-08" @default.
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- W3210568900 date "2019-09-27" @default.
- W3210568900 modified "2023-09-22" @default.
- W3210568900 title "Molecular dynamic of the methionyl-tRNA synthetase and its novel non-canonical functions in the yeast S. cerevisiae" @default.
- W3210568900 hasPublicationYear "2019" @default.
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