Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210654350> ?p ?o ?g. }
- W3210654350 abstract "Immune checkpoint inhibitors (ICIs) have provided tremendous clinical benefit in several cancer types. However, systemic activation of the immune system also leads to several immune-related adverse events. Of these, ICI-mediated colitis (IMC) occurs frequently and is the one with the highest absolute fatality. To improve current treatment strategies, it is important to understand the cellular mechanisms that induce this form of colitis. In this review, we discuss important pathways that are altered in IMC in mouse models and in human colon biopsy samples. This reveals a complex interplay between several types of immune cells and the gut microbiome. In addition to a mechanistic understanding, patients at risk should be identifiable before ICI therapy. Here we propose to focus on T-cell subsets that interact with bacteria after inducing epithelial damage. Especially, intestinal resident immune cells are of interest. This may lead to a better understanding of IMC and provides opportunities for prevention and management." @default.
- W3210654350 created "2021-11-08" @default.
- W3210654350 creator A5012962911 @default.
- W3210654350 creator A5017611205 @default.
- W3210654350 creator A5019881060 @default.
- W3210654350 creator A5024569067 @default.
- W3210654350 creator A5033556021 @default.
- W3210654350 creator A5042013205 @default.
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- W3210654350 creator A5054219763 @default.
- W3210654350 creator A5058463503 @default.
- W3210654350 creator A5069478712 @default.
- W3210654350 creator A5078135711 @default.
- W3210654350 date "2021-10-29" @default.
- W3210654350 modified "2023-10-17" @default.
- W3210654350 title "Mechanisms of Immune Checkpoint Inhibitor-Mediated Colitis" @default.
- W3210654350 cites W1228965893 @default.
- W3210654350 cites W1585402342 @default.
- W3210654350 cites W1664299218 @default.
- W3210654350 cites W1825306962 @default.
- W3210654350 cites W1916602633 @default.
- W3210654350 cites W1919200564 @default.
- W3210654350 cites W1947705102 @default.
- W3210654350 cites W1967067685 @default.
- W3210654350 cites W1973722969 @default.
- W3210654350 cites W1975515319 @default.
- W3210654350 cites W1977475153 @default.
- W3210654350 cites W1978820698 @default.
- W3210654350 cites W1984245017 @default.
- W3210654350 cites W1990295999 @default.
- W3210654350 cites W2001439253 @default.
- W3210654350 cites W2004400175 @default.
- W3210654350 cites W2007807635 @default.
- W3210654350 cites W2008617601 @default.
- W3210654350 cites W2009253992 @default.
- W3210654350 cites W2014257728 @default.
- W3210654350 cites W2016320681 @default.
- W3210654350 cites W2019022043 @default.
- W3210654350 cites W2028195000 @default.
- W3210654350 cites W2039123767 @default.
- W3210654350 cites W2042757960 @default.
- W3210654350 cites W2044200527 @default.
- W3210654350 cites W2049126749 @default.
- W3210654350 cites W2049657114 @default.
- W3210654350 cites W2061071534 @default.
- W3210654350 cites W2067401763 @default.
- W3210654350 cites W2073247934 @default.
- W3210654350 cites W2078258915 @default.
- W3210654350 cites W2087401044 @default.
- W3210654350 cites W2093785176 @default.
- W3210654350 cites W2097599737 @default.
- W3210654350 cites W2102876017 @default.
- W3210654350 cites W2107150019 @default.
- W3210654350 cites W2107752337 @default.
- W3210654350 cites W2108854943 @default.
- W3210654350 cites W2123968827 @default.
- W3210654350 cites W2124251804 @default.
- W3210654350 cites W2131950300 @default.
- W3210654350 cites W2132784721 @default.
- W3210654350 cites W2133607388 @default.
- W3210654350 cites W2135573233 @default.
- W3210654350 cites W2136859769 @default.
- W3210654350 cites W2137599445 @default.
- W3210654350 cites W2137712039 @default.
- W3210654350 cites W2141768998 @default.
- W3210654350 cites W2142231675 @default.
- W3210654350 cites W2143935698 @default.
- W3210654350 cites W2145887384 @default.
- W3210654350 cites W2155464214 @default.
- W3210654350 cites W2158792250 @default.
- W3210654350 cites W2162423605 @default.
- W3210654350 cites W2162442785 @default.
- W3210654350 cites W2162805528 @default.
- W3210654350 cites W2163855374 @default.
- W3210654350 cites W2164510587 @default.
- W3210654350 cites W2165456770 @default.
- W3210654350 cites W2166662937 @default.
- W3210654350 cites W2179205612 @default.
- W3210654350 cites W2211069246 @default.
- W3210654350 cites W2270932386 @default.
- W3210654350 cites W2275606382 @default.
- W3210654350 cites W2284831904 @default.
- W3210654350 cites W2292645700 @default.
- W3210654350 cites W2401419008 @default.
- W3210654350 cites W2519982410 @default.
- W3210654350 cites W2551653151 @default.
- W3210654350 cites W2572174216 @default.
- W3210654350 cites W2581283430 @default.
- W3210654350 cites W2588366403 @default.
- W3210654350 cites W2591239368 @default.
- W3210654350 cites W2591431100 @default.
- W3210654350 cites W2595325983 @default.
- W3210654350 cites W2601055810 @default.
- W3210654350 cites W2608694312 @default.
- W3210654350 cites W2619091826 @default.
- W3210654350 cites W2622111008 @default.
- W3210654350 cites W2625395613 @default.
- W3210654350 cites W2626773261 @default.
- W3210654350 cites W2672184770 @default.
- W3210654350 cites W2736166064 @default.