Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210679129> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3210679129 endingPage "100570" @default.
- W3210679129 startingPage "100570" @default.
- W3210679129 abstract "This study aimed to investigate miR-3682 as a biomarker in hepatocellular carcinoma (HCC).MiRNA and RNA profiles of 375 HCC tissues and 50 normal liver samples were downloaded from The Cancer Genome Atlas (TCGA) database. Multivariate Cox regression and Kaplan-Meier analyses were applied to examine the prognostic value of factors. Target genes of miR-3682 were analyzed by TargetScan and dual-luciferase reporter assay. Online Database for Annotation, Visualization, and Integrated Discovery (DAVID) to perform KEGG pathway enrichment. Cell counting kit-8, colony formation and migration and invasion assays were performed to analyze biological behaviors of HCC cells.MiR-3682 was identified to be highly expressed in HCC tissues and cell lines. And miR-3682 was negatively and independently associated with the outcome of HCC patients. Inhibition of miR-3682 suppressed HCC cell viability and mobility. ADRA1A, predicted and confirmed as the novel target of miR-3682, was an independent and positive prognostic predictor for HCC. In addition, the knockdown of ADRA1A partially offset the inhibitory effect of miR-3682 inhibitor on the growth and mobility of HCC cells. DAVID enrichment and western blot of key signaling-related proteins analyses revealed that miR-3682 inactivated 5'-AMP-activated protein kinase (AMPK) signaling by negatively regulating ADRA1A. Mechanically, it was partially through suppressing AMPK signaling via targeting ADRA1A that miR-3682 supported the HCC cell malignant phenotype.This study implicates that miR-3682 plays an oncogenetic role in HCC and can be considered a novel therapeutic target and prognostic indicator of HCC." @default.
- W3210679129 created "2021-11-08" @default.
- W3210679129 creator A5037259942 @default.
- W3210679129 creator A5051108910 @default.
- W3210679129 date "2022-01-01" @default.
- W3210679129 modified "2023-10-09" @default.
- W3210679129 title "MiR-3682 promotes the progression of hepatocellular carcinoma (HCC) via inactivating AMPK signaling by targeting ADRA1A" @default.
- W3210679129 cites W144423133 @default.
- W3210679129 cites W2005576365 @default.
- W3210679129 cites W2018080595 @default.
- W3210679129 cites W2041949855 @default.
- W3210679129 cites W2049407111 @default.
- W3210679129 cites W2061726552 @default.
- W3210679129 cites W2064656431 @default.
- W3210679129 cites W2076572520 @default.
- W3210679129 cites W2081920342 @default.
- W3210679129 cites W2123387119 @default.
- W3210679129 cites W2132308708 @default.
- W3210679129 cites W2136537452 @default.
- W3210679129 cites W2152989188 @default.
- W3210679129 cites W2298302134 @default.
- W3210679129 cites W2404879104 @default.
- W3210679129 cites W2474501870 @default.
- W3210679129 cites W2485812469 @default.
- W3210679129 cites W2560292853 @default.
- W3210679129 cites W2580345641 @default.
- W3210679129 cites W2590266658 @default.
- W3210679129 cites W2748787958 @default.
- W3210679129 cites W2763871199 @default.
- W3210679129 cites W2773835590 @default.
- W3210679129 cites W2794234124 @default.
- W3210679129 cites W2801167100 @default.
- W3210679129 cites W2921283762 @default.
- W3210679129 cites W2947172716 @default.
- W3210679129 cites W2970649863 @default.
- W3210679129 cites W2972495352 @default.
- W3210679129 cites W2991727328 @default.
- W3210679129 cites W2999417355 @default.
- W3210679129 cites W3008262230 @default.
- W3210679129 cites W3016759209 @default.
- W3210679129 doi "https://doi.org/10.1016/j.aohep.2021.100570" @default.
- W3210679129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34706275" @default.
- W3210679129 hasPublicationYear "2022" @default.
- W3210679129 type Work @default.
- W3210679129 sameAs 3210679129 @default.
- W3210679129 citedByCount "4" @default.
- W3210679129 countsByYear W32106791292022 @default.
- W3210679129 countsByYear W32106791292023 @default.
- W3210679129 crossrefType "journal-article" @default.
- W3210679129 hasAuthorship W3210679129A5037259942 @default.
- W3210679129 hasAuthorship W3210679129A5051108910 @default.
- W3210679129 hasBestOaLocation W32106791291 @default.
- W3210679129 hasConcept C126322002 @default.
- W3210679129 hasConcept C134018914 @default.
- W3210679129 hasConcept C184235292 @default.
- W3210679129 hasConcept C2778019345 @default.
- W3210679129 hasConcept C2780124434 @default.
- W3210679129 hasConcept C502942594 @default.
- W3210679129 hasConcept C71924100 @default.
- W3210679129 hasConcept C86803240 @default.
- W3210679129 hasConcept C95444343 @default.
- W3210679129 hasConcept C97029542 @default.
- W3210679129 hasConceptScore W3210679129C126322002 @default.
- W3210679129 hasConceptScore W3210679129C134018914 @default.
- W3210679129 hasConceptScore W3210679129C184235292 @default.
- W3210679129 hasConceptScore W3210679129C2778019345 @default.
- W3210679129 hasConceptScore W3210679129C2780124434 @default.
- W3210679129 hasConceptScore W3210679129C502942594 @default.
- W3210679129 hasConceptScore W3210679129C71924100 @default.
- W3210679129 hasConceptScore W3210679129C86803240 @default.
- W3210679129 hasConceptScore W3210679129C95444343 @default.
- W3210679129 hasConceptScore W3210679129C97029542 @default.
- W3210679129 hasLocation W32106791291 @default.
- W3210679129 hasLocation W32106791292 @default.
- W3210679129 hasLocation W32106791293 @default.
- W3210679129 hasOpenAccess W3210679129 @default.
- W3210679129 hasPrimaryLocation W32106791291 @default.
- W3210679129 hasRelatedWork W1966504330 @default.
- W3210679129 hasRelatedWork W1966775726 @default.
- W3210679129 hasRelatedWork W1979139803 @default.
- W3210679129 hasRelatedWork W1991560548 @default.
- W3210679129 hasRelatedWork W2030889776 @default.
- W3210679129 hasRelatedWork W2037631372 @default.
- W3210679129 hasRelatedWork W2040058909 @default.
- W3210679129 hasRelatedWork W2063957970 @default.
- W3210679129 hasRelatedWork W2132898409 @default.
- W3210679129 hasRelatedWork W4249176446 @default.
- W3210679129 hasVolume "27" @default.
- W3210679129 isParatext "false" @default.
- W3210679129 isRetracted "false" @default.
- W3210679129 magId "3210679129" @default.
- W3210679129 workType "article" @default.