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• W3210695713 startingPage "e10141" @default.
• W3210695713 abstract "Tumor relapse from treatment-resistant cells (minimal residual disease, MRD) underlies most breast cancer-related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here, we integrated multi-omics data from a tractable organoid system with a metabolic modeling approach to uncover the metabolic and regulatory idiosyncrasies of the MRD. We find that the resistant cells, despite their non-proliferative phenotype and the absence of oncogenic signaling, feature increased glycolysis and activity of certain urea cycle enzyme reminiscent of the tumor. This metabolic distinctiveness was also evident in a mouse model and in transcriptomic data from patients following neo-adjuvant therapy. We further identified a marked similarity in DNA methylation profiles between tumor and residual cells. Taken together, our data reveal a metabolic and epigenetic memory of the treatment-resistant cells. We further demonstrate that the memorized elevated glycolysis in MRD is crucial for their survival and can be targeted using a small-molecule inhibitor without impacting normal cells. The metabolic aberrances of MRD thus offer new therapeutic opportunities for post-treatment care to prevent breast tumor recurrence." @default.
• W3210695713 created "2021-11-08" @default.
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• W3210695713 date "2021-10-01" @default.
• W3210695713 modified "2023-10-17" @default.
• W3210695713 title "Metabolic memory underlying minimal residual disease in breast cancer." @default.
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• W3210695713 doi "https://doi.org/10.15252/msb.202010141" @default.
• W3210695713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8543468" @default.
• W3210695713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34694069" @default.
• W3210695713 hasPublicationYear "2021" @default.
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