Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210734041> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3210734041 abstract "Breast cancer (BC) is a common malignancy among women, and microRNAs (miRNAs) play a role in its progression. Reportedly, microRNA-4521 (miR-4521) participates in regulating the progression of some carcinomas. In the present work, miR-4521 and hepatoma up-regulated protein (HURP) mRNA expressions in BC tissues and cell lines were examined by qRT-PCR. After miR-4521 was overexpressed or knocked down in BC cells, CCK-8 experiment and EdU experiment were employed to detect BC cell growth. Moreover, the Transwell assay was adopted to detect the migration and invasion. Subsequently, flow cytometry was executed to evaluate the changes in cell cycle progression. KEGG analysis was utilized to predict the signaling pathways related with the target genes of miR-524-5p. The binding relationship between miR-4521 and HURP 3'UTR was validated by dual-luciferase reporter gene experiment. HURP and NF-kB p65 protein expression in BC cells was detected by Western blot. It was revealed that, miR-4521 was lowly expressed in BC tissues, and its expression was associated with tumor grade, lymph node metastasis and clinical stage of the patients. Overexpression of miR-4521 suppressed the growth, migration, invasion and cell cycle progression of BC cells and restrained p65 expression; downregulation of miR-4521 in BC cells showed opposite biological effects. Additionally, HURP was a downstream target gene of miR-4521, and overexpression of HURP reversed the above effects of miR-4521 overexpression. In short, miR-4521 can inhibit BC progression by modulating the HURP/NF-κB pathway." @default.
- W3210734041 created "2021-11-08" @default.
- W3210734041 creator A5053740664 @default.
- W3210734041 creator A5055835029 @default.
- W3210734041 creator A5076863238 @default.
- W3210734041 date "2021-10-26" @default.
- W3210734041 modified "2023-09-27" @default.
- W3210734041 title "MicroRNA-4521 targets hepatoma up-regulated protein (HURP) to inhibit the malignant progression of breast cancer" @default.
- W3210734041 cites W2068240232 @default.
- W3210734041 cites W2150679096 @default.
- W3210734041 cites W2293390255 @default.
- W3210734041 cites W2548805615 @default.
- W3210734041 cites W2744076112 @default.
- W3210734041 cites W2761809127 @default.
- W3210734041 cites W2907793726 @default.
- W3210734041 cites W2939860816 @default.
- W3210734041 cites W2945838677 @default.
- W3210734041 cites W2954866079 @default.
- W3210734041 cites W2974278475 @default.
- W3210734041 cites W2979816505 @default.
- W3210734041 cites W2980882117 @default.
- W3210734041 cites W2991430029 @default.
- W3210734041 cites W3015961005 @default.
- W3210734041 cites W3021568391 @default.
- W3210734041 cites W3038807013 @default.
- W3210734041 cites W3048358590 @default.
- W3210734041 cites W3106569755 @default.
- W3210734041 cites W3116273372 @default.
- W3210734041 cites W3120885630 @default.
- W3210734041 cites W3122953404 @default.
- W3210734041 doi "https://doi.org/10.1080/21655979.2021.1996016" @default.
- W3210734041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34699315" @default.
- W3210734041 hasPublicationYear "2021" @default.
- W3210734041 type Work @default.
- W3210734041 sameAs 3210734041 @default.
- W3210734041 citedByCount "0" @default.
- W3210734041 crossrefType "journal-article" @default.
- W3210734041 hasAuthorship W3210734041A5053740664 @default.
- W3210734041 hasAuthorship W3210734041A5055835029 @default.
- W3210734041 hasAuthorship W3210734041A5076863238 @default.
- W3210734041 hasBestOaLocation W32107340411 @default.
- W3210734041 hasConcept C104317684 @default.
- W3210734041 hasConcept C121608353 @default.
- W3210734041 hasConcept C126322002 @default.
- W3210734041 hasConcept C127561419 @default.
- W3210734041 hasConcept C145059251 @default.
- W3210734041 hasConcept C1491633281 @default.
- W3210734041 hasConcept C2776415932 @default.
- W3210734041 hasConcept C2779256057 @default.
- W3210734041 hasConcept C502942594 @default.
- W3210734041 hasConcept C54355233 @default.
- W3210734041 hasConcept C55493867 @default.
- W3210734041 hasConcept C62112901 @default.
- W3210734041 hasConcept C71924100 @default.
- W3210734041 hasConcept C86803240 @default.
- W3210734041 hasConceptScore W3210734041C104317684 @default.
- W3210734041 hasConceptScore W3210734041C121608353 @default.
- W3210734041 hasConceptScore W3210734041C126322002 @default.
- W3210734041 hasConceptScore W3210734041C127561419 @default.
- W3210734041 hasConceptScore W3210734041C145059251 @default.
- W3210734041 hasConceptScore W3210734041C1491633281 @default.
- W3210734041 hasConceptScore W3210734041C2776415932 @default.
- W3210734041 hasConceptScore W3210734041C2779256057 @default.
- W3210734041 hasConceptScore W3210734041C502942594 @default.
- W3210734041 hasConceptScore W3210734041C54355233 @default.
- W3210734041 hasConceptScore W3210734041C55493867 @default.
- W3210734041 hasConceptScore W3210734041C62112901 @default.
- W3210734041 hasConceptScore W3210734041C71924100 @default.
- W3210734041 hasConceptScore W3210734041C86803240 @default.
- W3210734041 hasLocation W32107340411 @default.
- W3210734041 hasLocation W32107340412 @default.
- W3210734041 hasLocation W32107340413 @default.
- W3210734041 hasOpenAccess W3210734041 @default.
- W3210734041 hasPrimaryLocation W32107340411 @default.
- W3210734041 hasRelatedWork W2573992804 @default.
- W3210734041 hasRelatedWork W2738575927 @default.
- W3210734041 hasRelatedWork W2907903807 @default.
- W3210734041 hasRelatedWork W2943758353 @default.
- W3210734041 hasRelatedWork W2979705150 @default.
- W3210734041 hasRelatedWork W2980649317 @default.
- W3210734041 hasRelatedWork W3141118674 @default.
- W3210734041 hasRelatedWork W4200546604 @default.
- W3210734041 hasRelatedWork W4211028039 @default.
- W3210734041 hasRelatedWork W4241300757 @default.
- W3210734041 isParatext "false" @default.
- W3210734041 isRetracted "false" @default.
- W3210734041 magId "3210734041" @default.
- W3210734041 workType "article" @default.