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• W3210738553 abstract "This study aimed to determine the role of CD161+CD4+ T cells in chronic hepatitis B virus (HBV) infection.A total of 94 patients with chronic hepatitis B (CHB), 73 with liver cirrhosis (LC) and 28 healthy controls were enrolled to determine frequency, cytokine production and chemokine receptor expression of circulating CD161+CD4+ T cells. Among these, 50 CHB and 34 LC patients were followed up for a period of 52-week entecavir monotherapy to assess the association of CD161+CD4+ T cells with seroconversion of HBV e antigen (HBeAg). In addition, 15 patients with hepatocellular carcinoma (HCC) and 15 with hepatic haemangioma (HHA) were enrolled to compare the paired circulating and intrahepatic CD161+CD4+ T cells.CD161+CD4+ T cells were found to accumulate in the circulation of HBV cohorts, which showed a significant correlation with the clinical parameters of disease progression. In addition, higher numbers of circulating CD161+CD4+ T cells were associated with an improved serological response of HBeAg to antiviral treatment. Moreover, CD161+CD4+ T cells as compared to homologous CD161-CD4+ T cells produced more pro-inflammatory cytokines including interleukin (IL)-17 and interferon (IFN)-γ and expressed higher levels of liver-homing chemokine receptors including CCR6, CXCR6 and CX3CR1. Notably, a significant enrichment of CD161+CD4+ T cell subsets co-expressing IFN-γ and IL-17 was observed in HBV-associated cirrhotic livers. During in vitro co-cultures, circulating CD161+CD4+ T cells in the chronic HBV setting exhibited prominent pro-fibrogenic effects by regulating primary hepatic stellate cells through a regenerative IFN-γ/IL-23/IL-17 axis.In chronic HBV infection, CD161+CD4+ T cells play antiviral, pro-inflammatory and pro-fibrogenic roles." @default.
• W3210738553 created "2021-11-08" @default.
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• W3210738553 date "2021-01-01" @default.
• W3210738553 modified "2023-10-16" @default.
• W3210738553 title "IFN‐γ facilitates liver fibrogenesis by CD161 ⁺ CD4 ⁺ T cells through a regenerative IL‐23/IL‐17 axis in chronic hepatitis B virus infection" @default.
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• W3210738553 doi "https://doi.org/10.1002/cti2.1353" @default.
• W3210738553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8563156" @default.
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