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- W3210761120 abstract "Purpose: The outcome for gallbladder cancer (GBC) is dependent on histopathology and radicality of the resection. The aim was to compare survival and recurrence after radical and non-radical procedure in incidental GBC (IGBC) and GBC patients. Methods: Data was collected from the national register SweLiv, including patients registered 2008-2019. Log Rank test was used for survival analysis, and multivariable proportional hazard regression analysis for adjustment of age, sex and pTN-stage. Results: In total 412 patients underwent resection (GBC) and 156 (IGBC) underwent reresection.On univariable analysis in patients with radical procedure an improved survival was seen in IGBC patients compared to GBC patients (HR: 0.61 CI: 0.38-0.96, p=0.033) and it sustained through multivariable analysis (HR: 0.60 CI: 0.37-0.95, p=0.029). Univariable subgroup analyses in patients after radical operation with pT1b and pT2 showed significant better survival for IGBC patients compared to GBC patients(HR: 0.27 CI: 0.094-0.78, p=0.016 and HR: 0.44 CI: 0.20-0.99, p=0.046). No significant difference in survival was seen between IGBC and GBC patients with a non-radical procedure, regardless of pTN-stage and adjustment for age and sex. Also, no significant difference was seen on recurrence among radically operated IGBC/GBC patients, including when adjusting for age, sex and pTN. Conclusion: On pT-specific analysis in patients with radical procedure, a significant better survival is seen in T1b and T2 IGBC patients compared to GBC patients. However, no significant difference is seen on survival in patients with a non-radical procedure and on recurrence among IGBC and GBC patients with an initially radical procedure." @default.
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- W3210761120 date "2021-01-01" @default.
- W3210761120 modified "2023-10-16" @default.
- W3210761120 title "Survival and recurrence after radical and non-radical procedure in incidental and nonincidental gallbladder cancer patients" @default.
- W3210761120 doi "https://doi.org/10.1016/j.hpb.2021.08.236" @default.
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