Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210879466> ?p ?o ?g. }
- W3210879466 endingPage "100411" @default.
- W3210879466 startingPage "100411" @default.
- W3210879466 abstract "Suicidal ideation and attempts (i.e., suicidality) are complex behaviors driven by environmental stress, genetic susceptibility, and their interaction. Preadolescent suicidality is a major health problem with rising rates, yet its underlying biology is understudied. Here we studied effects of genetic stress susceptibility, approximated by the polygenic risk score (PRS) for post-traumatic-stress-disorder (PTSD), on preadolescent suicidality in participants from the Adolescent Brain Cognitive Development (ABCD) Study®. We further evaluated PTSD-PRS effects on suicidality in the presence of environmental stressors that are established suicide risk factors. Analyses included both European and African ancestry participants using PRS calculated based on summary statistics from ancestry-specific genome-wide association studies. In European ancestry participants (N = 4,619, n = 378 suicidal), PTSD-PRS was associated with preadolescent suicidality (odds ratio [OR] = 1.12, 95%CI 1–1.25, p = 0.038). Results in African ancestry participants (N = 1,334, n = 130 suicidal) showed a similar direction but were not statistically significant (OR = 1.21, 95%CI 0.93–1.57, p = 0.153). Sensitivity analyses using non-psychiatric polygenic score for height and using cross-ancestry PTSD-PRS did not reveal any association with suicidality, supporting the specificity of the association of ancestry-specific PTSD-PRS with suicidality. Environmental stressors were robustly associated with suicidality across ancestries with moderate effect size for negative life events and family conflict (OR 1.27–1.6); and with large effect size (OR ∼ 4) for sexual-orientation discrimination. When combined with environmental factors, PTSD-PRS showed marginal additive effects in explaining variability in suicidality, with no evidence for G × E interaction. Results support use of cross-phenotype PRS, specifically stress-susceptibility, as a genetic marker for suicidality risk early in the lifespan." @default.
- W3210879466 created "2021-11-08" @default.
- W3210879466 creator A5001935511 @default.
- W3210879466 creator A5004366061 @default.
- W3210879466 creator A5010757095 @default.
- W3210879466 creator A5024432533 @default.
- W3210879466 creator A5035020346 @default.
- W3210879466 creator A5053038365 @default.
- W3210879466 creator A5057086671 @default.
- W3210879466 creator A5075485063 @default.
- W3210879466 creator A5078920096 @default.
- W3210879466 creator A5084393367 @default.
- W3210879466 date "2021-11-01" @default.
- W3210879466 modified "2023-10-17" @default.
- W3210879466 title "Contributions of PTSD polygenic risk and environmental stress to suicidality in preadolescents" @default.
- W3210879466 cites W1721687418 @default.
- W3210879466 cites W1819509872 @default.
- W3210879466 cites W1982409462 @default.
- W3210879466 cites W1983302342 @default.
- W3210879466 cites W2002494096 @default.
- W3210879466 cites W2058031168 @default.
- W3210879466 cites W2099085143 @default.
- W3210879466 cites W2102213696 @default.
- W3210879466 cites W2150581383 @default.
- W3210879466 cites W2213350231 @default.
- W3210879466 cites W2510973425 @default.
- W3210879466 cites W2560534764 @default.
- W3210879466 cites W2584469054 @default.
- W3210879466 cites W2756260596 @default.
- W3210879466 cites W2790273005 @default.
- W3210879466 cites W2803011420 @default.
- W3210879466 cites W2803124645 @default.
- W3210879466 cites W2804590196 @default.
- W3210879466 cites W2913350866 @default.
- W3210879466 cites W2924041626 @default.
- W3210879466 cites W2932671560 @default.
- W3210879466 cites W2945445235 @default.
- W3210879466 cites W2946249569 @default.
- W3210879466 cites W2948055130 @default.
- W3210879466 cites W2951553270 @default.
- W3210879466 cites W2963160524 @default.
- W3210879466 cites W2964961432 @default.
- W3210879466 cites W2965054109 @default.
- W3210879466 cites W2973023737 @default.
- W3210879466 cites W2979737847 @default.
- W3210879466 cites W2979994192 @default.
- W3210879466 cites W2981875455 @default.
- W3210879466 cites W3005723944 @default.
- W3210879466 cites W3011390203 @default.
- W3210879466 cites W3021472336 @default.
- W3210879466 cites W3027296401 @default.
- W3210879466 cites W3030752355 @default.
- W3210879466 cites W3047439085 @default.
- W3210879466 cites W3087169771 @default.
- W3210879466 cites W3092074878 @default.
- W3210879466 cites W3114344314 @default.
- W3210879466 cites W3125060799 @default.
- W3210879466 cites W4237462033 @default.
- W3210879466 doi "https://doi.org/10.1016/j.ynstr.2021.100411" @default.
- W3210879466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8569631" @default.
- W3210879466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34765698" @default.
- W3210879466 hasPublicationYear "2021" @default.
- W3210879466 type Work @default.
- W3210879466 sameAs 3210879466 @default.
- W3210879466 citedByCount "9" @default.
- W3210879466 countsByYear W32108794662022 @default.
- W3210879466 countsByYear W32108794662023 @default.
- W3210879466 crossrefType "journal-article" @default.
- W3210879466 hasAuthorship W3210879466A5001935511 @default.
- W3210879466 hasAuthorship W3210879466A5004366061 @default.
- W3210879466 hasAuthorship W3210879466A5010757095 @default.
- W3210879466 hasAuthorship W3210879466A5024432533 @default.
- W3210879466 hasAuthorship W3210879466A5035020346 @default.
- W3210879466 hasAuthorship W3210879466A5053038365 @default.
- W3210879466 hasAuthorship W3210879466A5057086671 @default.
- W3210879466 hasAuthorship W3210879466A5075485063 @default.
- W3210879466 hasAuthorship W3210879466A5078920096 @default.
- W3210879466 hasAuthorship W3210879466A5084393367 @default.
- W3210879466 hasBestOaLocation W32108794661 @default.
- W3210879466 hasConcept C104317684 @default.
- W3210879466 hasConcept C118552586 @default.
- W3210879466 hasConcept C125370674 @default.
- W3210879466 hasConcept C126322002 @default.
- W3210879466 hasConcept C134362201 @default.
- W3210879466 hasConcept C135763542 @default.
- W3210879466 hasConcept C142853389 @default.
- W3210879466 hasConcept C153209595 @default.
- W3210879466 hasConcept C156957248 @default.
- W3210879466 hasConcept C15744967 @default.
- W3210879466 hasConcept C161890455 @default.
- W3210879466 hasConcept C169594400 @default.
- W3210879466 hasConcept C190385971 @default.
- W3210879466 hasConcept C2776641880 @default.
- W3210879466 hasConcept C2993137441 @default.
- W3210879466 hasConcept C3017944768 @default.
- W3210879466 hasConcept C542102704 @default.
- W3210879466 hasConcept C54355233 @default.
- W3210879466 hasConcept C70410870 @default.