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- W3210881946 abstract "Brivaracetam (BRV) is the latest approved antiepileptic drug and acts as a high-affinity Synaptic Vesicle protein2A (SV2A) ligandthat exceeds the binding potential of Levetiracetam (LEV). In the European Union, BRV is only approved as an adjunctive therapyfor the treatment of Partial-Onset Seizures (POS) with or without secondary generalization, in patients 4 years of age and olderwith epilepsy, while F.D.A. has recently approved its use as monotherapy in partial-onset seizures in adults. In Phase III clinicaltrials, BRV has shown efficacy and an adequate safety profile in patients suffering from POS. In additional open-label studies, BRVhas demonstrated satisfying results and high retention rates in patients with both focal – onset and genetic generalized epilepsies.The main Treatment-Emergent Adverse Events (TEAEs) observed during the regulatory and open label trials were somnolence,dizziness and headache following by fatigue and nausea. Brivaracetam seems to be an effective, easy to use and safe antiepilepticdrug in clinical setting." @default.
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- W3210881946 date "2021-03-17" @default.
- W3210881946 modified "2023-09-23" @default.
- W3210881946 title "Overexpression of Neuregulin-1 Type III has Impact onVisual Function in Mice" @default.
- W3210881946 doi "https://doi.org/10.32474/ojnbd.2021.05.000215" @default.
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