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• W3210907293 abstract "The clinical relevance of bone remodelling predictions calls for accurate finite element (FE) modelling of implant-bone structure and musculoskeletal loading conditions. However, simplifications in muscle loading, material properties, has often been used in FE simulations. Bone adaptation induces changes in bone apparent density and its microstructure. Multiscale simulations, involving optimization methods and biomimetic microstructural models, have proven to be promising for predicting changes in bone morphology. The objective of the study is to develop a novel computational framework to predict bone remodelling around an uncemented femoral implant, using multiscale topology optimization and a parameterized cellular model. The efficacy of the scheme was evaluated by comparing the remodelling predictions with those of isotropic strain energy density (SED) and orthotropy based formulations. The characteristic functional groups and low-density regions of Ward's triangle, predicted by the optimization scheme, were comparable to micro-CT images of the proximal femur. Although the optimization scheme predicted well comparable material distribution in the 2D femur models, the obscured material orientations in some planes of the 3D model indicate the need for a more robust modelling of the boundary conditions. Regression analysis revealed a higher correlation (0.6472) between the topology optimization and SED models than the orthotropic predictions (0.4219). Despite higher bone apposition of 10-20% around the distal tip of the implant, the bone density distributions were well comparable to clinical observations towards the proximal femur. The proposed computational scheme appears to be a viable method for including bone anisotropy in the remodelling formulation." @default.
• W3210907293 created "2021-11-08" @default.
• W3210907293 creator A5039944092 @default.
• W3210907293 creator A5072494203 @default.
• W3210907293 creator A5085317025 @default.
• W3210907293 date "2022-01-01" @default.
• W3210907293 modified "2023-10-14" @default.
• W3210907293 title "Bone remodelling in implanted proximal femur using topology optimization and parameterized cellular model" @default.
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• W3210907293 doi "https://doi.org/10.1016/j.jmbbm.2021.104903" @default.
• W3210907293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34717117" @default.
• W3210907293 hasPublicationYear "2022" @default.
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