FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210989486> ?p ?o ?g. }

• W3210989486 endingPage "63" @default.
• W3210989486 startingPage "49" @default.
• W3210989486 abstract "Intestinal failure-associated liver disease (IFALD) increases mortality of patients with intestinal failure (IF), but lacks effective prevention or treatment approaches. Bile acids, gut microbiota and the host have close and complex interactions, which play a central role in modulating host immune and metabolic homeostasis. Increasing evidence suggests that derangement of the bile acid-gut microbiota (BA-GM) axis contributes to the development of IFALD.To review the BA-GM axis in the pathogenesis and clinical applications of IFALD, and to explore future directions for effective disease management.We conducted a literature search on bile acid and gut microbiota in IF and liver diseases.The BA-GM axis demonstrates a unique IF signature manifesting as an increase in primary-to-secondary bile acids ratio, disturbed enterohepatic circulation, blunted bile acid signalling pathways, gut microbial dysbiosis, and altered microbial metabolic outputs. Bile acids and gut microbiota shape the compositional and functional alterations of each other in IF; collaboratively, they promote immune dysfunction and metabolic aberration in the liver. Diagnostic markers and treatments targeting the BA-GM axis showed promising potential in the management of IFALD.Bile acids and gut microbiota play a central role in the development of IFALD and make attractive biomarkers as well as therapeutic targets. A multitarget, individualised therapy aiming at different parts of the BA-GM axis may provide optimal clinical benefits and requires future investigation." @default.
• W3210989486 created "2021-11-08" @default.
• W3210989486 creator A5010056672 @default.
• W3210989486 creator A5033906003 @default.
• W3210989486 creator A5048826252 @default.
• W3210989486 creator A5049715698 @default.
• W3210989486 creator A5064901415 @default.
• W3210989486 creator A5068134036 @default.
• W3210989486 creator A5070346853 @default.
• W3210989486 creator A5084443520 @default.
• W3210989486 date "2021-10-29" @default.
• W3210989486 modified "2023-10-10" @default.
• W3210989486 title "Review article: insights into the bile acid‐gut microbiota axis in intestinal failure‐associated liver disease—redefining the treatment approach" @default.
• W3210989486 cites W1534017202 @default.
• W3210989486 cites W153718458 @default.
• W3210989486 cites W1548699695 @default.
• W3210989486 cites W1559776411 @default.
• W3210989486 cites W1963587340 @default.
• W3210989486 cites W1966909187 @default.
• W3210989486 cites W1966922165 @default.
• W3210989486 cites W1967066877 @default.
• W3210989486 cites W1969883021 @default.
• W3210989486 cites W1972544609 @default.
• W3210989486 cites W1974616640 @default.
• W3210989486 cites W1976006475 @default.
• W3210989486 cites W1976884876 @default.
• W3210989486 cites W1978070564 @default.
• W3210989486 cites W1978332406 @default.
• W3210989486 cites W1980096836 @default.
• W3210989486 cites W1982099507 @default.
• W3210989486 cites W1985410296 @default.
• W3210989486 cites W1985640080 @default.
• W3210989486 cites W1989353297 @default.
• W3210989486 cites W1991765430 @default.
• W3210989486 cites W1992621882 @default.
• W3210989486 cites W1992875107 @default.
• W3210989486 cites W1993830991 @default.
• W3210989486 cites W2001334607 @default.
• W3210989486 cites W2002418675 @default.
• W3210989486 cites W2002515063 @default.
• W3210989486 cites W2005895469 @default.
• W3210989486 cites W2006386173 @default.
• W3210989486 cites W2012623473 @default.
• W3210989486 cites W2012927700 @default.
• W3210989486 cites W2013810471 @default.
• W3210989486 cites W2015958721 @default.
• W3210989486 cites W2017475253 @default.
• W3210989486 cites W2017675109 @default.
• W3210989486 cites W2023630186 @default.
• W3210989486 cites W2025699904 @default.
• W3210989486 cites W2026658658 @default.
• W3210989486 cites W2031682069 @default.
• W3210989486 cites W2032410285 @default.
• W3210989486 cites W2034106555 @default.
• W3210989486 cites W2035779227 @default.
• W3210989486 cites W2037805762 @default.
• W3210989486 cites W2041327155 @default.
• W3210989486 cites W2041827858 @default.
• W3210989486 cites W2042112823 @default.
• W3210989486 cites W2046887024 @default.
• W3210989486 cites W2049391209 @default.
• W3210989486 cites W2049506766 @default.
• W3210989486 cites W2051115786 @default.
• W3210989486 cites W2052527505 @default.
• W3210989486 cites W2053431969 @default.
• W3210989486 cites W2056654237 @default.
• W3210989486 cites W2060115626 @default.
• W3210989486 cites W2061365952 @default.
• W3210989486 cites W2070803377 @default.
• W3210989486 cites W2071030431 @default.
• W3210989486 cites W2073578515 @default.
• W3210989486 cites W2076259225 @default.
• W3210989486 cites W2079809637 @default.
• W3210989486 cites W2081271380 @default.
• W3210989486 cites W2083337853 @default.
• W3210989486 cites W2084831309 @default.
• W3210989486 cites W2085260006 @default.
• W3210989486 cites W2088781465 @default.
• W3210989486 cites W2090429237 @default.
• W3210989486 cites W2094171697 @default.
• W3210989486 cites W2094768453 @default.
• W3210989486 cites W2095063281 @default.
• W3210989486 cites W2096418655 @default.
• W3210989486 cites W2096595394 @default.
• W3210989486 cites W2097094398 @default.
• W3210989486 cites W2098919774 @default.
• W3210989486 cites W2101842666 @default.
• W3210989486 cites W2103038927 @default.
• W3210989486 cites W2104582722 @default.
• W3210989486 cites W2106760509 @default.
• W3210989486 cites W2106768039 @default.
• W3210989486 cites W2107206594 @default.
• W3210989486 cites W2119543164 @default.
• W3210989486 cites W2120419639 @default.
• W3210989486 cites W2122860085 @default.
• W3210989486 cites W2123561714 @default.
• W3210989486 cites W2124073413 @default.
• W3210989486 cites W2126377012 @default.

• next