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• W3210999481 abstract "Introduction: Liver Cirrhosis (LC) is a substantial health burden in the USA. Renal Failure (RF) is a common problem encountered in liver cirrhosis patients. There is limited data on the impact of renal failure on the outcome of liver cirrhosis. We utilized the National Inpatient Sample (NIS) to understand the effect of renal failure on inpatient mortality in LC patients. Methods: This is a retrospective study utilizing the data obtained from the 2017 National Inpatient Sample (NIS). We used the NIS database for RF, LC, and other comorbidities codes. The primary outcome was inpatient mortality. Secondary outcomes were hospital length of stay and cost utilization. We ran multivariate logistic regression analysis in STATA MP 16.1. Various confounding comorbidities were included. These included the previous history of coronary artery disease (CAD), congestive heart failure (CHF), smoking, hyperlipidemia (HLD), myocardial infarction (MI), alcohol intake (AI), diabetes mellitus (DM), obesity, peripheral artery disease (PAD), hypovolemia and hypotension. Results: The liver cirrhosis patients under investigation were all adults more than 18 years of age and numbered 40239 patients. The mean age was 57.3 years. Among these, 39% were females. While examining inpatient mortality, we see that for patients that had RF, the odds of inpatient mortality are higher (Odds Ratio (OR) 4.96, p = 0.000, 95% Confidence Interval (CI) 4.42 – 5.56). History of hypotension (OR 1.74, P = 0.000, 95% CI 1.52-1.99) also appears to contribute towards higher odds of mortality. The effect of other comorbidities was not statistically or clinically significant. Mean LOS was 5.7 days. Patients with RF stayed in the hospital longer by ∼3.0 days (Coef. 2.81, 95% CI 2.66 – 3.05). LOS was higher in patients with hypotension (1.90, 95% CI 1.60-2.22), hypovolemia (1.29, 95% CI 0.65- 1.93). The total charge for hospitalizations from RF is higher by $43527 (95% CI 37956 – 49097). Other factors incurring higher costs include the history of hypotension, hypovolemia, Hispanic/Asian race, and teaching hospitals (Table). Conclusion: This study suggests that the presence of renal failure in hospitalized patients with liver cirrhosis causes higher mortality, a longer length of stay, and a higher cost of hospitalization. This highlights that early identifying patients at high risk for AKI should be implemented to reduce mortality and contain costs.Table 1.: Mortality, LOS and Total Hospital Charge." @default.
• W3210999481 created "2021-11-08" @default.
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• W3210999481 date "2021-10-01" @default.
• W3210999481 modified "2023-10-16" @default.
• W3210999481 title "S3392 Effect of Renal Failure on Hospital-Based Outcomes in Patients With Liver Cirrhosis: Nationwide Sample Database" @default.
• W3210999481 doi "https://doi.org/10.14309/01.ajg.0000787100.85235.19" @default.
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