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- W3211001981 abstract "Cynanchum acutum L. is a climbing vine that belongs to the family Apocynaceae. Using different chromatographic techniques, seven compounds were isolated from the methanolic extract of the plant. The isolated compounds include six flavonoid compounds identified as rutin (1), quercetin-3-O-neohesperidoside (2), quercetin-3-O-β-galactoside (3), isoquercitrin (4), quercetin (5), and kaempferol 3-O-β-glucoside (6), in addition to a coumarin, scopoletin (7). The structures of the compounds were elucidated based on 1D NMR spectroscopy and high-resolution mass spectrometry (HR-MS), and by comparison with data reported in the literature. The first five compounds were selected for in vivo investigation of their anti-inflammatory and antioxidant properties in a rat model of type 2 diabetes. All tested compounds significantly reduced oxidative stress and increased erythrocyte lysate levels of antioxidant enzymes, along with the amelioration of the serum levels of inflammatory markers. Upregulation of miR-146a expression and downregulation of nuclear factor kappa B (NF-κB) expression were detected in the liver and adipose tissue of rats treated with the isolated flavonoids. Results from the biological investigation and those from the validated molecular modeling approach on two biological targets of the NF-κB pathway managed to highlight the superior anti-inflammatory activity of quercetin-3-O-galactoside (3) and quercetin (5), as compared to other bioactive metabolites." @default.
- W3211001981 created "2021-11-08" @default.
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- W3211001981 date "2021-10-27" @default.
- W3211001981 modified "2023-10-16" @default.
- W3211001981 title "Antioxidant and Anti-Inflammatory Activity of Cynanchum acutum L. Isolated Flavonoids Using Experimentally Induced Type 2 Diabetes Mellitus: Biological and In Silico Investigation for NF-κB Pathway/miR-146a Expression Modulation" @default.
- W3211001981 cites W1563843074 @default.
- W3211001981 cites W1771373428 @default.
- W3211001981 cites W1785230843 @default.
- W3211001981 cites W1902538798 @default.
- W3211001981 cites W1930485256 @default.
- W3211001981 cites W1936992221 @default.
- W3211001981 cites W1965307211 @default.
- W3211001981 cites W1974394264 @default.
- W3211001981 cites W1980377432 @default.
- W3211001981 cites W1995352580 @default.
- W3211001981 cites W1998450288 @default.
- W3211001981 cites W1999647730 @default.
- W3211001981 cites W2003060907 @default.
- W3211001981 cites W2005311098 @default.
- W3211001981 cites W2010297681 @default.
- W3211001981 cites W2013285507 @default.
- W3211001981 cites W2015284016 @default.
- W3211001981 cites W2018749567 @default.
- W3211001981 cites W2019221616 @default.
- W3211001981 cites W2020265334 @default.
- W3211001981 cites W2026497156 @default.
- W3211001981 cites W2031640592 @default.
- W3211001981 cites W2034586402 @default.
- W3211001981 cites W2037546430 @default.
- W3211001981 cites W2041091082 @default.
- W3211001981 cites W2044195489 @default.
- W3211001981 cites W2053974807 @default.
- W3211001981 cites W2061509198 @default.
- W3211001981 cites W2064647661 @default.
- W3211001981 cites W2067643341 @default.
- W3211001981 cites W2067740038 @default.
- W3211001981 cites W2068017935 @default.
- W3211001981 cites W2068038099 @default.
- W3211001981 cites W2070296547 @default.
- W3211001981 cites W2072552461 @default.
- W3211001981 cites W2073882423 @default.
- W3211001981 cites W2075860675 @default.
- W3211001981 cites W2082646732 @default.
- W3211001981 cites W2083974519 @default.
- W3211001981 cites W2087104779 @default.
- W3211001981 cites W2090981739 @default.
- W3211001981 cites W2095693480 @default.
- W3211001981 cites W2098199767 @default.
- W3211001981 cites W2116060738 @default.
- W3211001981 cites W2120532705 @default.
- W3211001981 cites W2120780444 @default.
- W3211001981 cites W2121079193 @default.
- W3211001981 cites W2126327417 @default.
- W3211001981 cites W2128027185 @default.
- W3211001981 cites W2130993490 @default.
- W3211001981 cites W2139197405 @default.
- W3211001981 cites W2144288821 @default.
- W3211001981 cites W2160234571 @default.
- W3211001981 cites W2161386296 @default.
- W3211001981 cites W2172688163 @default.
- W3211001981 cites W2263073154 @default.
- W3211001981 cites W2273608446 @default.
- W3211001981 cites W2317617138 @default.
- W3211001981 cites W2327991516 @default.
- W3211001981 cites W2413642082 @default.
- W3211001981 cites W2475580206 @default.
- W3211001981 cites W2505369960 @default.
- W3211001981 cites W2558250647 @default.
- W3211001981 cites W2565383127 @default.
- W3211001981 cites W2572254662 @default.
- W3211001981 cites W2588600506 @default.
- W3211001981 cites W2589560596 @default.
- W3211001981 cites W2613711128 @default.
- W3211001981 cites W2735527928 @default.
- W3211001981 cites W2754203730 @default.
- W3211001981 cites W2755181058 @default.
- W3211001981 cites W2801087259 @default.
- W3211001981 cites W2802806467 @default.
- W3211001981 cites W2810204213 @default.
- W3211001981 cites W2811390459 @default.
- W3211001981 cites W2887609842 @default.
- W3211001981 cites W2888275064 @default.
- W3211001981 cites W2908488634 @default.
- W3211001981 cites W2909321814 @default.
- W3211001981 cites W2913232622 @default.
- W3211001981 cites W2914944042 @default.
- W3211001981 cites W2934146212 @default.
- W3211001981 cites W2942974576 @default.