FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211035428> ?p ?o ?g. }

• W3211035428 endingPage "11345" @default.
• W3211035428 startingPage "11345" @default.
• W3211035428 abstract "TP53 plays critical roles in maintaining genome stability. Deleterious genetic variants damage the function of TP53, causing genome instability and increased cancer risk. Of the large quantity of genetic variants identified in TP53, however, many remain functionally unclassified as variants of unknown significance (VUS) due to the lack of evidence. This is reflected by the presence of 749 (42%) VUS of the 1785 germline variants collected in the ClinVar database. In this study, we addressed the deleteriousness of TP53 missense VUS. Utilizing the protein structure-based Ramachandran Plot-Molecular Dynamics Simulation (RPMDS) method that we developed, we measured the effects of missense VUS on TP53 structural stability. Of the 340 missense VUS tested, we observed deleterious evidence for 193 VUS, as reflected by the TP53 structural changes caused by the VUS-substituted residues. We compared the results from RPMDS with those from other in silico methods and observed higher specificity of RPMDS in classification of TP53 missense VUS than these methods. Data from our current study address a long-standing challenge in classifying the missense VUS in TP53, one of the most important tumor suppressor genes." @default.
• W3211035428 created "2021-11-08" @default.
• W3211035428 creator A5001797437 @default.
• W3211035428 creator A5032330103 @default.
• W3211035428 creator A5038179826 @default.
• W3211035428 creator A5075995315 @default.
• W3211035428 date "2021-10-20" @default.
• W3211035428 modified "2023-10-18" @default.
• W3211035428 title "Comprehensive Identification of Deleterious TP53 Missense VUS Variants Based on Their Impact on TP53 Structural Stability" @default.
• W3211035428 cites W1972978214 @default.
• W3211035428 cites W1973429805 @default.
• W3211035428 cites W1980740976 @default.
• W3211035428 cites W1981021420 @default.
• W3211035428 cites W1984576497 @default.
• W3211035428 cites W1986076152 @default.
• W3211035428 cites W1991494214 @default.
• W3211035428 cites W2004360551 @default.
• W3211035428 cites W2009783224 @default.
• W3211035428 cites W2014747507 @default.
• W3211035428 cites W2051409228 @default.
• W3211035428 cites W2051628563 @default.
• W3211035428 cites W2051978340 @default.
• W3211035428 cites W2059013803 @default.
• W3211035428 cites W2059145105 @default.
• W3211035428 cites W2065283382 @default.
• W3211035428 cites W2069452349 @default.
• W3211035428 cites W2081693079 @default.
• W3211035428 cites W2082103873 @default.
• W3211035428 cites W2086995400 @default.
• W3211035428 cites W2090291378 @default.
• W3211035428 cites W2099407940 @default.
• W3211035428 cites W2099459640 @default.
• W3211035428 cites W2101412130 @default.
• W3211035428 cites W2103616303 @default.
• W3211035428 cites W2108966286 @default.
• W3211035428 cites W2111326065 @default.
• W3211035428 cites W2114029728 @default.
• W3211035428 cites W2129952088 @default.
• W3211035428 cites W2132629607 @default.
• W3211035428 cites W2161013696 @default.
• W3211035428 cites W2161978970 @default.
• W3211035428 cites W2298876126 @default.
• W3211035428 cites W2312839459 @default.
• W3211035428 cites W2472035483 @default.
• W3211035428 cites W2521967673 @default.
• W3211035428 cites W2583025663 @default.
• W3211035428 cites W2774647756 @default.
• W3211035428 cites W2890179300 @default.
• W3211035428 cites W2905452503 @default.
• W3211035428 cites W2911270413 @default.
• W3211035428 cites W2945976633 @default.
• W3211035428 cites W2949598989 @default.
• W3211035428 cites W3110494028 @default.
• W3211035428 cites W3133491579 @default.
• W3211035428 cites W4255375128 @default.
• W3211035428 doi "https://doi.org/10.3390/ijms222111345" @default.
• W3211035428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8583684" @default.
• W3211035428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34768775" @default.
• W3211035428 hasPublicationYear "2021" @default.
• W3211035428 type Work @default.
• W3211035428 sameAs 3211035428 @default.
• W3211035428 citedByCount "4" @default.
• W3211035428 countsByYear W32110354282022 @default.
• W3211035428 countsByYear W32110354282023 @default.
• W3211035428 crossrefType "journal-article" @default.
• W3211035428 hasAuthorship W3211035428A5001797437 @default.
• W3211035428 hasAuthorship W3211035428A5032330103 @default.
• W3211035428 hasAuthorship W3211035428A5038179826 @default.
• W3211035428 hasAuthorship W3211035428A5075995315 @default.
• W3211035428 hasBestOaLocation W32110354281 @default.
• W3211035428 hasConcept C104317684 @default.
• W3211035428 hasConcept C109825262 @default.
• W3211035428 hasConcept C13514818 @default.
• W3211035428 hasConcept C141231307 @default.
• W3211035428 hasConcept C2775905019 @default.
• W3211035428 hasConcept C36823959 @default.
• W3211035428 hasConcept C501734568 @default.
• W3211035428 hasConcept C54355233 @default.
• W3211035428 hasConcept C70721500 @default.
• W3211035428 hasConcept C75563809 @default.
• W3211035428 hasConcept C86803240 @default.
• W3211035428 hasConceptScore W3211035428C104317684 @default.
• W3211035428 hasConceptScore W3211035428C109825262 @default.
• W3211035428 hasConceptScore W3211035428C13514818 @default.
• W3211035428 hasConceptScore W3211035428C141231307 @default.
• W3211035428 hasConceptScore W3211035428C2775905019 @default.
• W3211035428 hasConceptScore W3211035428C36823959 @default.
• W3211035428 hasConceptScore W3211035428C501734568 @default.
• W3211035428 hasConceptScore W3211035428C54355233 @default.
• W3211035428 hasConceptScore W3211035428C70721500 @default.
• W3211035428 hasConceptScore W3211035428C75563809 @default.
• W3211035428 hasConceptScore W3211035428C86803240 @default.
• W3211035428 hasIssue "21" @default.
• W3211035428 hasLocation W32110354281 @default.
• W3211035428 hasLocation W32110354282 @default.
• W3211035428 hasLocation W32110354283 @default.
• W3211035428 hasLocation W32110354284 @default.
• W3211035428 hasOpenAccess W3211035428 @default.

• next