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- W3211056893 abstract "Fabry disease (FD, OMIM 301500) is an X-linked lysosomal storage disease caused by pathogenic variants in the GLA gene. Cardiac involvement is common in FD and is responsible for impaired quality of life and premature death. The classic cardiac involvement is a nonobstructive form of hypertrophic cardiomyopathy, usually manifesting as concentric left ventricular hypertrophy, with subsequent arrhythmogenic intramural fibrosis. Treatment of patients with FD should be directed to prevent the disease progression to irreversible organ damage and organ failure. The aim of this review is to describe the current state of knowledge regarding cardiovascular involvement in FD, focusing on clinical and instrumental features, cardiovascular management, and targeted therapy." @default.
- W3211056893 created "2021-11-08" @default.
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- W3211056893 date "2022-01-01" @default.
- W3211056893 modified "2023-10-14" @default.
- W3211056893 title "Diagnosis and Management of Cardiovascular Involvement in Fabry Disease" @default.
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