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- W3211062415 abstract "Integrins are the adhesion molecules and transmembrane receptors that consist of α and β subunits. After binding to extracellular matrix components, integrins trigger intracellular signaling and regulate a wide spectrum of cellular functions, including cell survival, proliferation, differentiation and migration. Since the pattern of integrins expression is a key determinant of cell behavior in response to microenvironmental cues, deregulation of integrins caused by various mechanisms has been causally linked to cancer development and progression in several solid tumor types. In this review, we discuss the integrin signalosome with a highlight of a few key pro-oncogenic pathways elicited by integrins, and uncover the mutational and transcriptomic landscape of integrin-encoding genes across human cancers. In addition, we focus on the integrin-mediated control of cancer stem cell and tumor stemness in general, such as tumor initiation, epithelial plasticity, organotropic metastasis and drug resistance. With insights into how integrins contribute to the stem-like functions, we now gain better understanding of the integrin signalosome, which will greatly assist novel therapeutic development and more precise clinical decisions." @default.
- W3211062415 created "2021-11-08" @default.
- W3211062415 creator A5013343905 @default.
- W3211062415 creator A5033411069 @default.
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- W3211062415 creator A5072060416 @default.
- W3211062415 creator A5073531557 @default.
- W3211062415 date "2021-10-29" @default.
- W3211062415 modified "2023-10-18" @default.
- W3211062415 title "Integrins regulate stemness in solid tumor: an emerging therapeutic target" @default.
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