FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211069200> ?p ?o ?g. }

• W3211069200 endingPage "107301" @default.
• W3211069200 startingPage "107301" @default.
• W3211069200 abstract "Depending on environmental conditions, almost all proteins can form amyloid and amyloid-like aggregates that have unique functional properties. This opens numerous applications for designed aggregates in materials, medical and food applications. However, it is poorly understood how the amyloid (-like) aggregation and their resulting morphology is induced or influenced by various environmental and processing conditions. We identified and summarized conditions under which amyloid (-like) aggregates are formed and their impact on aggregate morphology. The focus is on β-lactoglobulin, but generic effects on other proteins are discussed, in order to elucidate common mechanistic properties. The flexibility of linear aggregates can be evaluated by comparing the persistence (Lp) and contour length (i.e., length when completely stretched; Lc). Shorter and more flexible amyloid-like aggregates (Lp < Lc) usually occur from a relatively fast assembly (e.g., low repulsion, high concentration, solvents). Longer, semi-flexible amyloid aggregates (Lp ∼ Lc) based on fibrillization-prone peptides that are slowly formed and assembled (e.g., high repulsion, low concentration). In either case, the aggregation kinetics increases through protein destabilization (e.g., heating, zinc addition, solvent and hydrolysis effects) and decreases through stabilization (e.g., glycerol addition). Post-processing (e.g., mechanical or interfacial stress) fragments aggregates into stiffer rods (Lp > Lc). Semi-flexible morphologies can align in liquid crystalline phases or interact with linear polysaccharides; while flexible aggregates can entangle. This allows for various possibilities to build higher order fibril or hybrid networks for various applications, such as bundles, coatings/films, or gels. This knowledge is crucial to produce specific morphologies for applications and to draw conclusions about how morphologies will be affected during processing (e.g., shearing)." @default.
• W3211069200 created "2021-11-08" @default.
• W3211069200 creator A5000027835 @default.
• W3211069200 creator A5013266398 @default.
• W3211069200 creator A5015755325 @default.
• W3211069200 creator A5026788988 @default.
• W3211069200 creator A5042258540 @default.
• W3211069200 creator A5063135330 @default.
• W3211069200 creator A5076602214 @default.
• W3211069200 creator A5081224678 @default.
• W3211069200 creator A5087866827 @default.
• W3211069200 creator A5088955480 @default.
• W3211069200 date "2022-03-01" @default.
• W3211069200 modified "2023-09-25" @default.
• W3211069200 title "Engineering amyloid and amyloid-like morphologies of β-lactoglobulin" @default.
• W3211069200 cites W1841796729 @default.
• W3211069200 cites W1964601834 @default.
• W3211069200 cites W1967819251 @default.
• W3211069200 cites W1975211202 @default.
• W3211069200 cites W1976201852 @default.
• W3211069200 cites W1976504048 @default.
• W3211069200 cites W1978270584 @default.
• W3211069200 cites W1985086778 @default.
• W3211069200 cites W1988728911 @default.
• W3211069200 cites W1989462447 @default.
• W3211069200 cites W1997723318 @default.
• W3211069200 cites W1998616370 @default.
• W3211069200 cites W1999354467 @default.
• W3211069200 cites W1999608634 @default.
• W3211069200 cites W2003114613 @default.
• W3211069200 cites W2003447842 @default.
• W3211069200 cites W2004098528 @default.
• W3211069200 cites W2007523574 @default.
• W3211069200 cites W2013098612 @default.
• W3211069200 cites W2019851417 @default.
• W3211069200 cites W2020069228 @default.
• W3211069200 cites W2024323623 @default.
• W3211069200 cites W2024534379 @default.
• W3211069200 cites W2025433912 @default.
• W3211069200 cites W2025815557 @default.
• W3211069200 cites W2027863241 @default.
• W3211069200 cites W2033433194 @default.
• W3211069200 cites W2035724894 @default.
• W3211069200 cites W2037435891 @default.
• W3211069200 cites W2041641336 @default.
• W3211069200 cites W2042827464 @default.
• W3211069200 cites W2050005958 @default.
• W3211069200 cites W2050693275 @default.
• W3211069200 cites W2053727980 @default.
• W3211069200 cites W2054212962 @default.
• W3211069200 cites W2054675242 @default.
• W3211069200 cites W2062894716 @default.
• W3211069200 cites W2069279800 @default.
• W3211069200 cites W2070018868 @default.
• W3211069200 cites W2076974640 @default.
• W3211069200 cites W2077190100 @default.
• W3211069200 cites W2077575537 @default.
• W3211069200 cites W2086994853 @default.
• W3211069200 cites W2090242110 @default.
• W3211069200 cites W2092901111 @default.
• W3211069200 cites W2093894883 @default.
• W3211069200 cites W2097330081 @default.
• W3211069200 cites W2100605364 @default.
• W3211069200 cites W2106427122 @default.
• W3211069200 cites W2124544960 @default.
• W3211069200 cites W2126531317 @default.
• W3211069200 cites W2126844486 @default.
• W3211069200 cites W2127758437 @default.
• W3211069200 cites W2128595832 @default.
• W3211069200 cites W2129507901 @default.
• W3211069200 cites W2134855238 @default.
• W3211069200 cites W2138698547 @default.
• W3211069200 cites W2149790826 @default.
• W3211069200 cites W2149975011 @default.
• W3211069200 cites W2150739009 @default.
• W3211069200 cites W2158119813 @default.
• W3211069200 cites W2165227163 @default.
• W3211069200 cites W2278203278 @default.
• W3211069200 cites W2313634493 @default.
• W3211069200 cites W2314730130 @default.
• W3211069200 cites W2318343937 @default.
• W3211069200 cites W2318905955 @default.
• W3211069200 cites W2319132861 @default.
• W3211069200 cites W2323406284 @default.
• W3211069200 cites W2323511515 @default.
• W3211069200 cites W2327124850 @default.
• W3211069200 cites W2334555401 @default.
• W3211069200 cites W2382261180 @default.
• W3211069200 cites W2488721898 @default.
• W3211069200 cites W2532287247 @default.
• W3211069200 cites W2581381516 @default.
• W3211069200 cites W2582285810 @default.
• W3211069200 cites W2594075639 @default.
• W3211069200 cites W2606393075 @default.
• W3211069200 cites W2619203867 @default.
• W3211069200 cites W2741140686 @default.
• W3211069200 cites W2757421672 @default.
• W3211069200 cites W2762440725 @default.

• next