FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211142434> ?p ?o ?g. }

• W3211142434 endingPage "401" @default.
• W3211142434 startingPage "387" @default.
• W3211142434 abstract "Loss of function of tuberous sclerosis complex 1 or 2 (TSC1 or TSC2) leads to the activation of mammalian target of rapamycin complex 1 (mTORC1). Hyperactivated mTORC1 plays a critical role in tumor growth, but the underlying mechanism is still not completely elucidated. Here, by analyzing Tsc1- or Tsc2-null mouse embryonic fibroblasts, rat Tsc2-null ELT3 cells, and human cancer cells, we present evidence for the involvement of epidermal growth factor receptor (EGFR) as a downstream target of mTORC1 in tumor growth. We show that mTORC1 leads to increased EGFR expression through upregulation of runt-related transcriptional factor 1 (RUNX1). Knockdown of EGFR impairs proliferation and tumoral growth of Tsc-deficient cells, while overexpression of EGFR promotes the proliferation of the control cells. Moreover, the mTOR signaling pathway has been shown to be positively correlated with EGFR in human cancers. In addition, we demonstrated that EGFR enhances cell growth through activation of signal transducer and activator of transcription 3 (STAT3). We conclude that activation of the RUNX1/EGFR/STAT3 signaling pathway contributes to tumorigenesis caused by hyperactivated mTORC1 and should be targeted for the treatment of mTORC1-related tumors, particularly TSC." @default.
• W3211142434 created "2021-11-08" @default.
• W3211142434 creator A5010185627 @default.
• W3211142434 creator A5025774272 @default.
• W3211142434 creator A5026771827 @default.
• W3211142434 creator A5028609590 @default.
• W3211142434 creator A5031572143 @default.
• W3211142434 creator A5035512909 @default.
• W3211142434 creator A5038142481 @default.
• W3211142434 creator A5064292215 @default.
• W3211142434 creator A5076610659 @default.
• W3211142434 creator A5077233021 @default.
• W3211142434 creator A5077455555 @default.
• W3211142434 creator A5082502526 @default.
• W3211142434 date "2021-12-01" @default.
• W3211142434 modified "2023-10-18" @default.
• W3211142434 title "RUNX1/EGFR pathway contributes to STAT3 activation and tumor growth caused by hyperactivated mTORC1" @default.
• W3211142434 cites W1773455335 @default.
• W3211142434 cites W1879729745 @default.
• W3211142434 cites W1967980682 @default.
• W3211142434 cites W1980532029 @default.
• W3211142434 cites W1984412362 @default.
• W3211142434 cites W1986194331 @default.
• W3211142434 cites W1998432624 @default.
• W3211142434 cites W2011282245 @default.
• W3211142434 cites W2011356964 @default.
• W3211142434 cites W2022633707 @default.
• W3211142434 cites W2028298372 @default.
• W3211142434 cites W2028544780 @default.
• W3211142434 cites W2035618305 @default.
• W3211142434 cites W2048983352 @default.
• W3211142434 cites W2054838993 @default.
• W3211142434 cites W2096057911 @default.
• W3211142434 cites W2097846011 @default.
• W3211142434 cites W2105932025 @default.
• W3211142434 cites W2106129342 @default.
• W3211142434 cites W2121208012 @default.
• W3211142434 cites W2160200374 @default.
• W3211142434 cites W2164930765 @default.
• W3211142434 cites W2167242172 @default.
• W3211142434 cites W2172202139 @default.
• W3211142434 cites W2194597307 @default.
• W3211142434 cites W2258318060 @default.
• W3211142434 cites W2340213079 @default.
• W3211142434 cites W2383259826 @default.
• W3211142434 cites W2548344412 @default.
• W3211142434 cites W2603052976 @default.
• W3211142434 cites W2607129810 @default.
• W3211142434 cites W2614655279 @default.
• W3211142434 cites W2615601352 @default.
• W3211142434 cites W2727299941 @default.
• W3211142434 cites W2803097984 @default.
• W3211142434 cites W2805942737 @default.
• W3211142434 cites W2886011147 @default.
• W3211142434 cites W2898144712 @default.
• W3211142434 cites W2901242178 @default.
• W3211142434 cites W2902948777 @default.
• W3211142434 cites W2941119008 @default.
• W3211142434 cites W2974546158 @default.
• W3211142434 cites W2981080598 @default.
• W3211142434 cites W2999390744 @default.
• W3211142434 cites W2999421965 @default.
• W3211142434 cites W3010541969 @default.
• W3211142434 cites W3011245685 @default.
• W3211142434 cites W3014696958 @default.
• W3211142434 cites W3109926818 @default.
• W3211142434 cites W3128272573 @default.
• W3211142434 cites W3159811077 @default.
• W3211142434 cites W3164370300 @default.
• W3211142434 doi "https://doi.org/10.1016/j.omto.2021.10.009" @default.
• W3211142434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8605091" @default.
• W3211142434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34853810" @default.
• W3211142434 hasPublicationYear "2021" @default.
• W3211142434 type Work @default.
• W3211142434 sameAs 3211142434 @default.
• W3211142434 citedByCount "10" @default.
• W3211142434 countsByYear W32111424342022 @default.
• W3211142434 countsByYear W32111424342023 @default.
• W3211142434 crossrefType "journal-article" @default.
• W3211142434 hasAuthorship W3211142434A5010185627 @default.
• W3211142434 hasAuthorship W3211142434A5025774272 @default.
• W3211142434 hasAuthorship W3211142434A5026771827 @default.
• W3211142434 hasAuthorship W3211142434A5028609590 @default.
• W3211142434 hasAuthorship W3211142434A5031572143 @default.
• W3211142434 hasAuthorship W3211142434A5035512909 @default.
• W3211142434 hasAuthorship W3211142434A5038142481 @default.
• W3211142434 hasAuthorship W3211142434A5064292215 @default.
• W3211142434 hasAuthorship W3211142434A5076610659 @default.
• W3211142434 hasAuthorship W3211142434A5077233021 @default.
• W3211142434 hasAuthorship W3211142434A5077455555 @default.
• W3211142434 hasAuthorship W3211142434A5082502526 @default.
• W3211142434 hasBestOaLocation W32111424341 @default.
• W3211142434 hasConcept C104317684 @default.
• W3211142434 hasConcept C121608353 @default.
• W3211142434 hasConcept C127561419 @default.
• W3211142434 hasConcept C171958077 @default.
• W3211142434 hasConcept C173396325 @default.
• W3211142434 hasConcept C2776773979 @default.

• next