Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211156913> ?p ?o ?g. }
- W3211156913 abstract "Abstract Parkinson’s disease (PD) is a progressive chronic neurodegenerative condition characterized by the loss of dopaminergic neurons within the substantia nigra. Current PD therapeutic strategies are mainly symptomatic and can lead to motor complications overtime. As a result, alternative medicine may provide an effective adjuvant treatment for PD as an addition to or as a replacement of the conventional therapies. The aim of this work was to evaluate the effects of Bee Venom (BV) and dopamine (DA)-loaded nanoparticles in a reserpine-induced animal model of PD. After inducing PD with reserpine injection, different groups of male rats were treated with L-Dopa, BV, DA-nanoparticles. Our findings showed that BV and DA-nanoparticles administration restored monoamines, balanced glutamate/GABA levels, halted DNA fragmentation, decreased pro-inflammatory mediators (IL-1β and TNF-α), and elevated anti-inflammatory mediators (PON1) and neurotropic factor (BDNF) levels in comparison with conventional therapy of PD. Furthermore, in a reserpine-induced PD rat model, the ameliorative effects of BV were significantly superior to that of DA-nanoparticles. These findings imply that BV and DA-nanoparticles could be useful as adjuvant treatments for PD." @default.
- W3211156913 created "2021-11-08" @default.
- W3211156913 creator A5031094220 @default.
- W3211156913 creator A5032408272 @default.
- W3211156913 creator A5045908040 @default.
- W3211156913 creator A5046526118 @default.
- W3211156913 creator A5066918677 @default.
- W3211156913 creator A5078027339 @default.
- W3211156913 creator A5090129814 @default.
- W3211156913 date "2021-10-27" @default.
- W3211156913 modified "2023-10-12" @default.
- W3211156913 title "Effects of bee venom and dopamine-loaded nanoparticles on reserpine-induced Parkinson’s disease rat model" @default.
- W3211156913 cites W119598809 @default.
- W3211156913 cites W1537019834 @default.
- W3211156913 cites W1770889999 @default.
- W3211156913 cites W1967443141 @default.
- W3211156913 cites W1971048984 @default.
- W3211156913 cites W1972742074 @default.
- W3211156913 cites W1975774284 @default.
- W3211156913 cites W1983581469 @default.
- W3211156913 cites W2029464988 @default.
- W3211156913 cites W2029549580 @default.
- W3211156913 cites W2032330024 @default.
- W3211156913 cites W2033705417 @default.
- W3211156913 cites W2040921716 @default.
- W3211156913 cites W2042996349 @default.
- W3211156913 cites W2043737083 @default.
- W3211156913 cites W2050742296 @default.
- W3211156913 cites W2053180614 @default.
- W3211156913 cites W2054848243 @default.
- W3211156913 cites W2059913761 @default.
- W3211156913 cites W2065175310 @default.
- W3211156913 cites W2066762007 @default.
- W3211156913 cites W2068058390 @default.
- W3211156913 cites W2069443216 @default.
- W3211156913 cites W2081173055 @default.
- W3211156913 cites W2082194970 @default.
- W3211156913 cites W2085270307 @default.
- W3211156913 cites W2093487114 @default.
- W3211156913 cites W2101072380 @default.
- W3211156913 cites W2106350754 @default.
- W3211156913 cites W2133712961 @default.
- W3211156913 cites W2142430469 @default.
- W3211156913 cites W2156179625 @default.
- W3211156913 cites W2165457285 @default.
- W3211156913 cites W2182962525 @default.
- W3211156913 cites W2237666958 @default.
- W3211156913 cites W2313395767 @default.
- W3211156913 cites W2408747271 @default.
- W3211156913 cites W2443322277 @default.
- W3211156913 cites W2464977649 @default.
- W3211156913 cites W2478503896 @default.
- W3211156913 cites W2535730691 @default.
- W3211156913 cites W2582399566 @default.
- W3211156913 cites W2597180564 @default.
- W3211156913 cites W2609509800 @default.
- W3211156913 cites W2619485834 @default.
- W3211156913 cites W2790357623 @default.
- W3211156913 cites W2797450108 @default.
- W3211156913 cites W2937515253 @default.
- W3211156913 cites W2942391262 @default.
- W3211156913 cites W2993536313 @default.
- W3211156913 cites W3003486628 @default.
- W3211156913 cites W3004443958 @default.
- W3211156913 cites W3015222991 @default.
- W3211156913 cites W3040311506 @default.
- W3211156913 cites W4250151684 @default.
- W3211156913 doi "https://doi.org/10.1038/s41598-021-00764-y" @default.
- W3211156913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8551202" @default.
- W3211156913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34707203" @default.
- W3211156913 hasPublicationYear "2021" @default.
- W3211156913 type Work @default.
- W3211156913 sameAs 3211156913 @default.
- W3211156913 citedByCount "6" @default.
- W3211156913 countsByYear W32111569132022 @default.
- W3211156913 countsByYear W32111569132023 @default.
- W3211156913 crossrefType "journal-article" @default.
- W3211156913 hasAuthorship W3211156913A5031094220 @default.
- W3211156913 hasAuthorship W3211156913A5032408272 @default.
- W3211156913 hasAuthorship W3211156913A5045908040 @default.
- W3211156913 hasAuthorship W3211156913A5046526118 @default.
- W3211156913 hasAuthorship W3211156913A5066918677 @default.
- W3211156913 hasAuthorship W3211156913A5078027339 @default.
- W3211156913 hasAuthorship W3211156913A5090129814 @default.
- W3211156913 hasBestOaLocation W32111569131 @default.
- W3211156913 hasConcept C126322002 @default.
- W3211156913 hasConcept C137183658 @default.
- W3211156913 hasConcept C185592680 @default.
- W3211156913 hasConcept C2776219046 @default.
- W3211156913 hasConcept C2777842393 @default.
- W3211156913 hasConcept C2779134260 @default.
- W3211156913 hasConcept C2779734285 @default.
- W3211156913 hasConcept C2780938664 @default.
- W3211156913 hasConcept C50156730 @default.
- W3211156913 hasConcept C513476851 @default.
- W3211156913 hasConcept C529278444 @default.
- W3211156913 hasConcept C71924100 @default.
- W3211156913 hasConcept C98274493 @default.
- W3211156913 hasConceptScore W3211156913C126322002 @default.
- W3211156913 hasConceptScore W3211156913C137183658 @default.