FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211211896> ?p ?o ?g. }

• W3211211896 abstract "Abstract The Nucleosome Remodeling and Deacetylase (NuRD) complex is one of the central chromatin remolding complexes that mediate gene repression. NuRD is essential for numerous developmental events, including heart development. Clinical and genetic studies have provided direct evidence for the role of chromodomain helicase DNA-binding protein 4 (CHD4), the catalytic component of NuRD, in congenital heart disease (CHD), including atrial and ventricular septal defects. Further, it has been demonstrated that CHD4 is essential for mammalian cardiomyocyte formation and function. A key unresolved question is how CHD4/NuRD is localized to specific cardiac targets genes, as neither CHD4 nor NuRD can directly bind DNA. Here, we coupled a bioinformatics-based approach with mass spectrometry analyses to demonstrate that CHD4 interacts with the core cardiac transcription factors GATA4, NKX2-5 and TBX5 during embryonic heart development. Using transcriptomics and genome-wide occupancy data, we have characterized the genomic landscape of GATA4, NKX2-5 and TBX5 repression and defined the direct cardiac gene targets of GATA4-CHD4, NKX2-5-CHD4 and TBX5-CHD4 complexes. These data were used to identify putative cis-regulatory elements regulated controlled by these complexes. We genetically interrogated two of these silencers in vivo, Acta1 and Myh11 . We show that deletion of these silencers leads to inappropriate skeletal and smooth muscle gene mis-expression, respectively, in the embryonic heart. These results delineate how CHD4/NuRD is localized to specific cardiac loci and explicates how mutations in the broadly expressed CHD4 protein lead to cardiac specific disease states." @default.
• W3211211896 created "2021-11-08" @default.
• W3211211896 creator A5001468756 @default.
• W3211211896 creator A5005006089 @default.
• W3211211896 creator A5005883610 @default.
• W3211211896 creator A5017541072 @default.
• W3211211896 creator A5028346312 @default.
• W3211211896 creator A5038046469 @default.
• W3211211896 creator A5041976491 @default.
• W3211211896 creator A5047437797 @default.
• W3211211896 creator A5050568621 @default.
• W3211211896 creator A5076662333 @default.
• W3211211896 creator A5091470716 @default.
• W3211211896 date "2021-10-28" @default.
• W3211211896 modified "2023-09-23" @default.
• W3211211896 title "CHD4 is recruited by GATA4 and NKX2-5 silencers to repress non-cardiac gene programs in the developing heart" @default.
• W3211211896 cites W1520697307 @default.
• W3211211896 cites W1535517524 @default.
• W3211211896 cites W1567517848 @default.
• W3211211896 cites W1857753605 @default.
• W3211211896 cites W1878240916 @default.
• W3211211896 cites W1964430638 @default.
• W3211211896 cites W1973431915 @default.
• W3211211896 cites W1973672022 @default.
• W3211211896 cites W1973949212 @default.
• W3211211896 cites W1981577585 @default.
• W3211211896 cites W1984159489 @default.
• W3211211896 cites W2010564453 @default.
• W3211211896 cites W2014677321 @default.
• W3211211896 cites W2017702380 @default.
• W3211211896 cites W2019127826 @default.
• W3211211896 cites W2020084014 @default.
• W3211211896 cites W2021341670 @default.
• W3211211896 cites W2036592751 @default.
• W3211211896 cites W2045998016 @default.
• W3211211896 cites W2047838358 @default.
• W3211211896 cites W2055597783 @default.
• W3211211896 cites W2060740961 @default.
• W3211211896 cites W2061483944 @default.
• W3211211896 cites W2065096062 @default.
• W3211211896 cites W2074353056 @default.
• W3211211896 cites W2074380974 @default.
• W3211211896 cites W2078475439 @default.
• W3211211896 cites W2082714048 @default.
• W3211211896 cites W2099060358 @default.
• W3211211896 cites W2104276565 @default.
• W3211211896 cites W2107688352 @default.
• W3211211896 cites W2117827556 @default.
• W3211211896 cites W2127387556 @default.
• W3211211896 cites W2136015585 @default.
• W3211211896 cites W2158626316 @default.
• W3211211896 cites W2159600984 @default.
• W3211211896 cites W2161673104 @default.
• W3211211896 cites W2168038023 @default.
• W3211211896 cites W2170830174 @default.
• W3211211896 cites W2171808845 @default.
• W3211211896 cites W2238514531 @default.
• W3211211896 cites W2259938310 @default.
• W3211211896 cites W2270976853 @default.
• W3211211896 cites W2337221221 @default.
• W3211211896 cites W2375204717 @default.
• W3211211896 cites W2398293253 @default.
• W3211211896 cites W2484900834 @default.
• W3211211896 cites W2500269539 @default.
• W3211211896 cites W2520557077 @default.
• W3211211896 cites W2603428373 @default.
• W3211211896 cites W2611551741 @default.
• W3211211896 cites W2729948611 @default.
• W3211211896 cites W2745854214 @default.
• W3211211896 cites W2782941307 @default.
• W3211211896 cites W2803671769 @default.
• W3211211896 cites W2808010282 @default.
• W3211211896 cites W2918677431 @default.
• W3211211896 cites W2921695314 @default.
• W3211211896 cites W2946082305 @default.
• W3211211896 cites W2946438015 @default.
• W3211211896 cites W2952527196 @default.
• W3211211896 cites W2952615074 @default.
• W3211211896 cites W2969292556 @default.
• W3211211896 cites W2972262587 @default.
• W3211211896 cites W2981904307 @default.
• W3211211896 cites W3002841239 @default.
• W3211211896 cites W3034418205 @default.
• W3211211896 cites W3169670957 @default.
• W3211211896 cites W3194562798 @default.
• W3211211896 doi "https://doi.org/10.1101/2021.10.28.466285" @default.
• W3211211896 hasPublicationYear "2021" @default.
• W3211211896 type Work @default.
• W3211211896 sameAs 3211211896 @default.
• W3211211896 citedByCount "0" @default.
• W3211211896 crossrefType "posted-content" @default.
• W3211211896 hasAuthorship W3211211896A5001468756 @default.
• W3211211896 hasAuthorship W3211211896A5005006089 @default.
• W3211211896 hasAuthorship W3211211896A5005883610 @default.
• W3211211896 hasAuthorship W3211211896A5017541072 @default.
• W3211211896 hasAuthorship W3211211896A5028346312 @default.
• W3211211896 hasAuthorship W3211211896A5038046469 @default.
• W3211211896 hasAuthorship W3211211896A5041976491 @default.
• W3211211896 hasAuthorship W3211211896A5047437797 @default.
• W3211211896 hasAuthorship W3211211896A5050568621 @default.

• next