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• W3211214198 abstract "Gastric cancer (GC) is one of the most lethal malignancies worldwide. However, the molecular mechanisms underlying gastric carcinogenesis remain largely unknown. Over the past decades, advances in RNA-sequencing techniques have greatly facilitated the identification of various non-coding RNAs (ncRNAs) in cancer cells, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Accumulating evidence has revealed that ncRNAs are essential regulators in GC occurrence and development. However, ncRNAs represent an emerging field of cancer research, and their complex functionality remains to be clarified. Considering the lack of viable biomarkers and therapeutic targets in GC, further studies should focus on elucidating the intricate relationships between ncRNAs and GC, which can be translated into clinical practice. In this review, we summarize recent research progress on how ncRNAs modulate the malignant hallmarks of GC, especially in tumor immune escape, drug resistance, and stemness. We also discuss the promising applications of ncRNAs as diagnostic biomarkers and therapeutic targets in GC, aiming to validate their practical value for clinical treatment." @default.
• W3211214198 created "2021-11-08" @default.
• W3211214198 creator A5026295742 @default.
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• W3211214198 creator A5069522797 @default.
• W3211214198 creator A5078046545 @default.
• W3211214198 creator A5083942110 @default.
• W3211214198 date "2021-11-03" @default.
• W3211214198 modified "2023-10-01" @default.
• W3211214198 title "Non-Coding RNAs in Gastric Cancer: From Malignant Hallmarks to Clinical Applications" @default.
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