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• W3211237881 abstract "Corpus luteum (CL), a transitory gland, undergoes rapid growth in a limited time to produce progesterone (P4) followed by its regression. A complex molecular signaling is involved in controlling luteal P4 production. In the present study, 2D gel electrophoresis-based proteomics and in silico functional analysis were used to identify changes in key proteins and pathways in CL along the different stages of the estrous cycle as its development progresses from early (Day 3) to mid-luteal phase (Day 9), effective functioning (Day 12) followed by regression (Day 15) or, in the case of pregnancy, rescue of function (Day 15). A total of 273 proteins were identified by MALDI-MS/MS analysis that showed significant changes in abundances at different stages of CL development or regression and rescue. Functional annotation of differentially abundant proteins suggested enrichment of several important pathways and functions during CL development and function maintenance including cell survival, endocytosis, oxidative stress response, estradiol metabolism, and angiogenesis. On the other hand, differentially abundant proteins during CL regression were associated with decreased steroid synthesis and metabolism and increased apoptosis, necrosis, and infiltration of immune cells. Establishment of pregnancy rescues CL from regression by maintaining the expression of proteins that support steroidogenesis as pathways such as the super-pathway of cholesterol biosynthesis, RhoA signaling, and functions such as fatty acid metabolism and sterol transport were enriched in CL of pregnancy. In this study, some novel proteins were identified along CL development that advances our understanding of CL survival and steroidogenesis." @default.
• W3211237881 created "2021-11-08" @default.
• W3211237881 creator A5010501773 @default.
• W3211237881 creator A5027531992 @default.
• W3211237881 creator A5088526027 @default.
• W3211237881 date "2021-10-29" @default.
• W3211237881 modified "2023-10-17" @default.
• W3211237881 title "Changes in Porcine Corpus Luteum Proteome Associated with Development, Maintenance, Regression, and Rescue during Estrous Cycle and Early Pregnancy" @default.
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• W3211237881 doi "https://doi.org/10.3390/ijms222111740" @default.
• W3211237881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8583735" @default.
• W3211237881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34769171" @default.
• W3211237881 hasPublicationYear "2021" @default.
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