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- W3211259511 abstract "Introduction: Morbidity after pancreatic resection for pancreatic ductal adenocarcinoma (PDAC) remains high and postoperative complications (POC) have been associated with oncologic results in other gastrointestinal tumours. This association remains controversial in PDAC. The aim of this study was to investigate the impact of POC on long-term overall survival (OS) and disease free survival (DFS) after curative resection for PDAC. Method: Perioperative characteristics of all patients who underwent curative resection for PDAC between 2000 and 2018 were analysed. Patients with Stage IV PDAC, other synchronous tumours and those who died within the first 90 postoperative days were excluded. Univariable and multivariable analyses were performed to determine the effect of POC and other demographic, tumor-related and perioperative variables on OS and DFS. Results: A total of 134 patients were included. Sixty-three patients (47%) suffered major POC (Clavien III-V). Univariable survival analysis showed that patients with POC had a significantly worse OS (19,57 vs 30,3 months; p = 0,028) and DFS (9,77 vs 15,13 months, p = 0,03) than those without POC. In multivariate survival analysis the presence of POC was an independent risk factor for decreased OS (HR 2,2; 95% confidence interval 1,12-4,31). Conclusion: The results of this study showed that postoperative complications have a negative impact on survival in patients undergoing curative resection for pancreatic ductal adenocarcinoma." @default.
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- W3211259511 date "2021-01-01" @default.
- W3211259511 modified "2023-10-16" @default.
- W3211259511 title "Effect of Postoperative Complications on Long-term Oncological Outcomes after Curative Resection for Pancreatic Cancer" @default.
- W3211259511 doi "https://doi.org/10.1016/j.hpb.2021.08.900" @default.
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