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- W3211265575 abstract "AbstractDuring laser-assisted cancer treatment, achieving a target-specific tumor ablation with minimum damage to surrounding normal tissues is a recent challenge. Nowadays, the various developments in nanotechnology include new techniques for this noninvasive photothermal tumor ablation process. A three-dimensional triple layered skin model with embedded tumor and countercurrent large blood vessels are chosen as the present computational domain. The diffusive heat equation in tissue and convective heat equation along with momentum equation in blood domain were solved using COMSOL Multiphysics (Bangalore, India) to predict the temperature field. The laser intensity distribution in tissue was modeled by modified Beer–Lambert law, whereas the tissue damage was predicted by solving the Arrhenius equation. A comparative study between intravenous (IV) and intratumoral (IT) infusion schemes of gold nanosphere (AuNp) was made considering both Pennes and the dual-phase lag (DPL) bioheat model to account the effect of relaxation time in bio-tissues. Numerical results show a better result for IT scheme in contrast to IV scheme in terms of tumor confined necrosis, sparing the neighboring healthy tissues and minimizing the heat sink effect of countercurrent blood vessels. During photothermal lesion ablation process, the effect of stratum corneum layer of skin is reflected by the differences in temperature plot at different layers of dermis, epidermis and subcutaneous. In an inhomogeneous tissue medium embedding AuNp clusters, the DPL model predicts more accurate results in terms of late thermal response to external laser irradiation as well as oscillating temperature history. The inclusion of relaxation times (tau_{q}) and (tau_{T}) in the DPL model enables the prediction of wavy characteristics of the thermal front that is traveling at a finite speed in biological tissue. Overall, the present computer simulation can improve the real clinical malignant tumor ablation process during laser-assisted thermotherapy.KeywordsMulti-layer skin modelCountercurrent blood flowTumor necrosisGold nanosphere" @default.
- W3211265575 created "2021-11-08" @default.
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- W3211265575 date "2021-10-22" @default.
- W3211265575 modified "2023-09-24" @default.
- W3211265575 title "Nanoparticle-Assisted Multilayered Photothermal Therapy Concerning Countercurrent Blood Flow: A Numerical Study" @default.
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- W3211265575 doi "https://doi.org/10.1007/978-981-16-3497-0_7" @default.
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