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• W3211291729 abstract "It has been hypothesized that epithelial-mesenchymal transition (EMT) may occur in the retinal pigment epithelium of advanced stage age-related macular degeneration (AMD). Various serum and plasma growth factors and inflammatory mediators have been linked to AMD. We were interested in finding out whether systemic levels of EMT-associated markers were altered in the serum of wet AMD patients. Serum biomarkers associated with the various pathological processes of AMD may present an avenue towards identifying and characterizing the birth mechanisms of wet AMD, its progression and severity, paving the way towards the application of precision medicine.We chose to measure the serum levels of known biomarkers of EMT - EGF (epidermal growth factor), ET-1 (endothelin 1), IL-8 (interleukin 8), TGF-β1 and TGF-β2 (transforming growth factor-beta 1 and 2) and VEGF-A (vascular endothelial growth factor A) - using enzyme-linked immunosorbent assays. We measured them from 71 Finnish wet AMD patients who were receiving intravitreal anti-VEGF-A injection treatments, as well as 64 age-adjusted controls.We found significantly elevated levels of ET-1, IL-8 and TGF-β2 in the serums of wet AMD patients.ET-1, IL-8 and TGF-β2 appear to be useful serum biomarkers in understanding active wet AMD. However, we cannot conclude that local retinal EMT-processes could be observed from the corresponding systemic serum biomarkers in patients undergoing anti-VEGF-A treatments." @default.
• W3211291729 created "2021-11-08" @default.
• W3211291729 creator A5021448617 @default.
• W3211291729 creator A5022005561 @default.
• W3211291729 creator A5038036691 @default.
• W3211291729 creator A5041681571 @default.
• W3211291729 creator A5042481813 @default.
• W3211291729 creator A5090858301 @default.
• W3211291729 date "2021-10-26" @default.
• W3211291729 modified "2023-10-06" @default.
• W3211291729 title "Epithelial–mesenchymal transition‐related serum markers ET‐1, IL‐8 and TGF‐β2 are elevated in a Finnish wet age‐related macular degeneration cohort" @default.
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