FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211294124> ?p ?o ?g. }

• W3211294124 endingPage "420" @default.
• W3211294124 startingPage "412" @default.
• W3211294124 abstract "Despite technological advances in mechanical circulatory support devices to treat end-stage heart failure, blood damage induced by non-physiological shear stress in operation often triggered clinical hemocompatibility complications. The loss of high molecular weight von Willebrand Factor (HMW-VWF) has been considered as an essential cause of gastrointestinal bleeding. In addition to the mechanics factors, interface factors may also affect blood damage, especially the surface characteristics. In this study, the effect of surface roughness on VWF damage under flow condition was investigated. A roller pump circulation experimental platform with a roughness embedded sample chamber was constructed to provide blood shearing flow condition. VWF molecular weight analysis, VWF antigen (VWF-Ag) concentration assay, and VWF ristocetin cofactor activity (VWF-Rico) assay were performed on the sheared blood samples. These variables are the main functional indicators of VWF. It was found that the surface roughness induced VWF damage is mainly caused by the loss of HMW-VWF rather than reducing the total amount of VWF. The threshold value of surface roughness for a rapid increase in the degradation of HMW-VWF under low flow rate was obtained between Ra 0.4 and 0.6 μm, which was smaller than the threshold for hemolysis. Our findings indicated that VWF is more sensitive to the interface factor of surface roughness than red blood cells, thus has a higher requirement for blood pump design. It could provide reference for the material design and processing in developing mechanical circulatory support devices." @default.
• W3211294124 created "2021-11-08" @default.
• W3211294124 creator A5020413416 @default.
• W3211294124 creator A5022242648 @default.
• W3211294124 creator A5032846110 @default.
• W3211294124 creator A5061372760 @default.
• W3211294124 creator A5071412979 @default.
• W3211294124 creator A5087450637 @default.
• W3211294124 date "2021-11-04" @default.
• W3211294124 modified "2023-10-13" @default.
• W3211294124 title "The influence of surface roughness on the damage of von Willebrand Factor under shear flow condition" @default.
• W3211294124 cites W140077311 @default.
• W3211294124 cites W1524108558 @default.
• W3211294124 cites W1967135328 @default.
• W3211294124 cites W1994879150 @default.
• W3211294124 cites W2006468999 @default.
• W3211294124 cites W2026511177 @default.
• W3211294124 cites W2027853064 @default.
• W3211294124 cites W2033408017 @default.
• W3211294124 cites W2034058223 @default.
• W3211294124 cites W2077702940 @default.
• W3211294124 cites W2080846011 @default.
• W3211294124 cites W2089727747 @default.
• W3211294124 cites W2095118408 @default.
• W3211294124 cites W2137827663 @default.
• W3211294124 cites W2412598514 @default.
• W3211294124 cites W2799981541 @default.
• W3211294124 cites W3002231813 @default.
• W3211294124 cites W3009470027 @default.
• W3211294124 cites W3009629309 @default.
• W3211294124 cites W3014160396 @default.
• W3211294124 cites W59066530 @default.
• W3211294124 doi "https://doi.org/10.1177/03913988211056961" @default.
• W3211294124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34736346" @default.
• W3211294124 hasPublicationYear "2021" @default.
• W3211294124 type Work @default.
• W3211294124 sameAs 3211294124 @default.
• W3211294124 citedByCount "5" @default.
• W3211294124 countsByYear W32112941242022 @default.
• W3211294124 countsByYear W32112941242023 @default.
• W3211294124 crossrefType "journal-article" @default.
• W3211294124 hasAuthorship W3211294124A5020413416 @default.
• W3211294124 hasAuthorship W3211294124A5022242648 @default.
• W3211294124 hasAuthorship W3211294124A5032846110 @default.
• W3211294124 hasAuthorship W3211294124A5061372760 @default.
• W3211294124 hasAuthorship W3211294124A5071412979 @default.
• W3211294124 hasAuthorship W3211294124A5087450637 @default.
• W3211294124 hasConcept C107365816 @default.
• W3211294124 hasConcept C12554922 @default.
• W3211294124 hasConcept C126322002 @default.
• W3211294124 hasConcept C136229726 @default.
• W3211294124 hasConcept C152279782 @default.
• W3211294124 hasConcept C159985019 @default.
• W3211294124 hasConcept C185592680 @default.
• W3211294124 hasConcept C192562407 @default.
• W3211294124 hasConcept C21141959 @default.
• W3211294124 hasConcept C2779394231 @default.
• W3211294124 hasConcept C2779902561 @default.
• W3211294124 hasConcept C71039073 @default.
• W3211294124 hasConcept C71924100 @default.
• W3211294124 hasConcept C86803240 @default.
• W3211294124 hasConcept C89560881 @default.
• W3211294124 hasConceptScore W3211294124C107365816 @default.
• W3211294124 hasConceptScore W3211294124C12554922 @default.
• W3211294124 hasConceptScore W3211294124C126322002 @default.
• W3211294124 hasConceptScore W3211294124C136229726 @default.
• W3211294124 hasConceptScore W3211294124C152279782 @default.
• W3211294124 hasConceptScore W3211294124C159985019 @default.
• W3211294124 hasConceptScore W3211294124C185592680 @default.
• W3211294124 hasConceptScore W3211294124C192562407 @default.
• W3211294124 hasConceptScore W3211294124C21141959 @default.
• W3211294124 hasConceptScore W3211294124C2779394231 @default.
• W3211294124 hasConceptScore W3211294124C2779902561 @default.
• W3211294124 hasConceptScore W3211294124C71039073 @default.
• W3211294124 hasConceptScore W3211294124C71924100 @default.
• W3211294124 hasConceptScore W3211294124C86803240 @default.
• W3211294124 hasConceptScore W3211294124C89560881 @default.
• W3211294124 hasFunder F4320321001 @default.
• W3211294124 hasFunder F4320321543 @default.
• W3211294124 hasFunder F4320322769 @default.
• W3211294124 hasIssue "4" @default.
• W3211294124 hasLocation W32112941241 @default.
• W3211294124 hasLocation W32112941242 @default.
• W3211294124 hasOpenAccess W3211294124 @default.
• W3211294124 hasPrimaryLocation W32112941241 @default.
• W3211294124 hasRelatedWork W1539029371 @default.
• W3211294124 hasRelatedWork W1949867050 @default.
• W3211294124 hasRelatedWork W2063375919 @default.
• W3211294124 hasRelatedWork W2349515859 @default.
• W3211294124 hasRelatedWork W2373610016 @default.
• W3211294124 hasRelatedWork W2378823047 @default.
• W3211294124 hasRelatedWork W2381790324 @default.
• W3211294124 hasRelatedWork W2390761163 @default.
• W3211294124 hasRelatedWork W2974638572 @default.
• W3211294124 hasRelatedWork W4319159815 @default.
• W3211294124 hasVolume "45" @default.
• W3211294124 isParatext "false" @default.
• W3211294124 isRetracted "false" @default.

• next