Matches in SemOpenAlex for { <https://semopenalex.org/work/W3211297921> ?p ?o ?g. }
- W3211297921 endingPage "1841" @default.
- W3211297921 startingPage "1841" @default.
- W3211297921 abstract "Inflammation is a key homeostatic process involved in the body’s response to a multitude of disease states including infection, autoimmune disorders, cancer, and other chronic conditions. When the initiating event is poorly controlled, severe inflammation and globally dysregulated immune responses can occur. To address the lack of therapies that efficaciously address the multiple aspects of the dysregulated immune response, we developed cargo-less immunomodulatory nanoparticles (iNPs) comprised of poly(lactic acid) (PLA) with either poly(vinyl alcohol) (PVA) or poly(ethylene-alt-maleic acid) (PEMA) as stabilizing surfactants and investigated the mechanisms by which they exert their inherent anti-inflammatory effects. We identified that iNPs leverage a multimodal mechanism of action by physically interfering with the interactions between pathogen-associated molecular patterns (PAMPs) and bone marrow-derived macrophages (BMMΦs). Additionally, we showed that iNPs mitigate proinflammatory cytokine secretions induced by LPS via a time- and composition-dependent abrogation of NF-κB p65 and p38 MAPK activation. Lastly, inhibition studies were performed to establish the role of a pH-sensing G-protein-coupled receptor, GPR68, on contributing to the activity of iNPs. These data provide evidence for the multimodal mechanism of action of iNPs and establish their potential use as a novel therapeutic for the treatment of severe inflammation." @default.
- W3211297921 created "2021-11-08" @default.
- W3211297921 creator A5009714554 @default.
- W3211297921 creator A5019486520 @default.
- W3211297921 creator A5023683841 @default.
- W3211297921 creator A5050939922 @default.
- W3211297921 creator A5053271274 @default.
- W3211297921 creator A5073114289 @default.
- W3211297921 creator A5073626775 @default.
- W3211297921 date "2021-11-02" @default.
- W3211297921 modified "2023-10-15" @default.
- W3211297921 title "Immunomodulatory Nanoparticles Mitigate Macrophage Inflammation via Inhibition of PAMP Interactions and Lactate-Mediated Functional Reprogramming of NF-κB and p38 MAPK" @default.
- W3211297921 cites W1967965268 @default.
- W3211297921 cites W1975182142 @default.
- W3211297921 cites W1991209345 @default.
- W3211297921 cites W2002427738 @default.
- W3211297921 cites W2004465286 @default.
- W3211297921 cites W2017749666 @default.
- W3211297921 cites W2029738113 @default.
- W3211297921 cites W2039854966 @default.
- W3211297921 cites W2046692671 @default.
- W3211297921 cites W2052474826 @default.
- W3211297921 cites W2056241473 @default.
- W3211297921 cites W2063632665 @default.
- W3211297921 cites W2065468254 @default.
- W3211297921 cites W2067673936 @default.
- W3211297921 cites W2072624182 @default.
- W3211297921 cites W2082083192 @default.
- W3211297921 cites W2083907713 @default.
- W3211297921 cites W2092235636 @default.
- W3211297921 cites W2104564237 @default.
- W3211297921 cites W2105731567 @default.
- W3211297921 cites W2105838733 @default.
- W3211297921 cites W2111428445 @default.
- W3211297921 cites W2112006829 @default.
- W3211297921 cites W2114741192 @default.
- W3211297921 cites W2125921464 @default.
- W3211297921 cites W2127795119 @default.
- W3211297921 cites W2142656871 @default.
- W3211297921 cites W2223946157 @default.
- W3211297921 cites W2338589974 @default.
- W3211297921 cites W2465126356 @default.
- W3211297921 cites W2527704261 @default.
- W3211297921 cites W2555739217 @default.
- W3211297921 cites W2588593853 @default.
- W3211297921 cites W2607023284 @default.
- W3211297921 cites W2762411375 @default.
- W3211297921 cites W2781695025 @default.
- W3211297921 cites W2786063237 @default.
- W3211297921 cites W2787216835 @default.
- W3211297921 cites W2897020726 @default.
- W3211297921 cites W2901824420 @default.
- W3211297921 cites W2913111458 @default.
- W3211297921 cites W2915498411 @default.
- W3211297921 cites W2923845811 @default.
- W3211297921 cites W2947020562 @default.
- W3211297921 cites W2954545712 @default.
- W3211297921 cites W2956865178 @default.
- W3211297921 cites W2982216374 @default.
- W3211297921 cites W2994511180 @default.
- W3211297921 cites W2998853022 @default.
- W3211297921 cites W3004735824 @default.
- W3211297921 cites W3047051440 @default.
- W3211297921 cites W3080945733 @default.
- W3211297921 cites W3088479058 @default.
- W3211297921 cites W3091854075 @default.
- W3211297921 cites W3092750669 @default.
- W3211297921 cites W3120128630 @default.
- W3211297921 cites W4211179700 @default.
- W3211297921 doi "https://doi.org/10.3390/pharmaceutics13111841" @default.
- W3211297921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8618039" @default.
- W3211297921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34834256" @default.
- W3211297921 hasPublicationYear "2021" @default.
- W3211297921 type Work @default.
- W3211297921 sameAs 3211297921 @default.
- W3211297921 citedByCount "14" @default.
- W3211297921 countsByYear W32112979212022 @default.
- W3211297921 countsByYear W32112979212023 @default.
- W3211297921 crossrefType "journal-article" @default.
- W3211297921 hasAuthorship W3211297921A5009714554 @default.
- W3211297921 hasAuthorship W3211297921A5019486520 @default.
- W3211297921 hasAuthorship W3211297921A5023683841 @default.
- W3211297921 hasAuthorship W3211297921A5050939922 @default.
- W3211297921 hasAuthorship W3211297921A5053271274 @default.
- W3211297921 hasAuthorship W3211297921A5073114289 @default.
- W3211297921 hasAuthorship W3211297921A5073626775 @default.
- W3211297921 hasBestOaLocation W32112979211 @default.
- W3211297921 hasConcept C164027704 @default.
- W3211297921 hasConcept C185592680 @default.
- W3211297921 hasConcept C202751555 @default.
- W3211297921 hasConcept C203014093 @default.
- W3211297921 hasConcept C2776914184 @default.
- W3211297921 hasConcept C2777730290 @default.
- W3211297921 hasConcept C2778690821 @default.
- W3211297921 hasConcept C2779244956 @default.
- W3211297921 hasConcept C502942594 @default.
- W3211297921 hasConcept C51551487 @default.
- W3211297921 hasConcept C55493867 @default.