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• W3211316411 endingPage "e0259265" @default.
• W3211316411 startingPage "e0259265" @default.
• W3211316411 abstract "We sought to identify plasma biomarkers associated with spontaneous preterm birth (SPTB, delivery within 21 days of sampling) in women with preterm labor (PTL) without intra-amniotic infection/inflammation (IAI) using label-free quantitative proteomic analysis, as well as to elucidate specific protein pathways involved in these cases.This was a retrospective cohort study comprising 104 singleton pregnant women with PTL (24-32 weeks) who underwent amniocentesis and demonstrated no evidence of IAI. Analysis of pooled plasma samples collected from SPTB cases and term birth (TB) controls (n = 10 for each group) was performed using label-free quantitative mass spectrometry for proteome profiling in a nested case-control study design. Eight candidate proteins of interest were validated by ELISA-based assay and a clot-based assay in the total cohort.Ninety-one proteins were differentially expressed (P < 0.05) in plasma samples obtained from SPTB cases, of which 53 (58.2%) were upregulated and 38 (41.8%) were downregulated when compared to TD controls. A validation study confirmed that plasma from women who delivered spontaneously within 21 days of sampling contained significantly higher levels of coagulation factor Ⅴ and lower levels of S100 calcium binding protein A9 (S100A9), especially the former which was independent of baseline variables. The top-ranked pathways related to the 91 differentially expressed proteins were liver-X-receptor/retinoid X receptor (RXR) activation, acute phase response signaling, farnesoid X receptor/RXR activation, coagulation system, and complement system.Proteomic analyses in this study identified potential novel biomarkers (i.e., coagulation factor V and S100A9) and potential protein pathways in plasma associated with SPTB in the absence of IAI in women with PTL. The present findings provide novel insights into the molecular pathogenesis and therapeutic targets specific for idiopathic SPTB." @default.
• W3211316411 created "2021-11-08" @default.
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• W3211316411 date "2021-10-28" @default.
• W3211316411 modified "2023-10-16" @default.
• W3211316411 title "Proteomic identification of novel plasma biomarkers associated with spontaneous preterm birth in women with preterm labor without infection/inflammation" @default.
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• W3211316411 cites W1903502948 @default.
• W3211316411 cites W1968611669 @default.
• W3211316411 cites W1968742530 @default.
• W3211316411 cites W1970172365 @default.
• W3211316411 cites W1970727168 @default.
• W3211316411 cites W1973778351 @default.
• W3211316411 cites W1974441529 @default.
• W3211316411 cites W1975755498 @default.
• W3211316411 cites W1979993841 @default.
• W3211316411 cites W1983378030 @default.
• W3211316411 cites W1985438653 @default.
• W3211316411 cites W1993271798 @default.
• W3211316411 cites W1994202942 @default.
• W3211316411 cites W1994317567 @default.
• W3211316411 cites W1994741050 @default.
• W3211316411 cites W2003169764 @default.
• W3211316411 cites W2004848041 @default.
• W3211316411 cites W2006683544 @default.
• W3211316411 cites W2008029664 @default.
• W3211316411 cites W2010101647 @default.
• W3211316411 cites W2013195978 @default.
• W3211316411 cites W2013442912 @default.
• W3211316411 cites W2020467083 @default.
• W3211316411 cites W2028315160 @default.
• W3211316411 cites W2032739461 @default.
• W3211316411 cites W2036265066 @default.
• W3211316411 cites W2038107183 @default.
• W3211316411 cites W2048514942 @default.
• W3211316411 cites W2048895471 @default.
• W3211316411 cites W2054218003 @default.
• W3211316411 cites W2056125312 @default.
• W3211316411 cites W2056228221 @default.
• W3211316411 cites W2060138131 @default.
• W3211316411 cites W2061902453 @default.
• W3211316411 cites W2063546126 @default.
• W3211316411 cites W2066290080 @default.
• W3211316411 cites W2067591042 @default.
• W3211316411 cites W2068318750 @default.
• W3211316411 cites W2082899534 @default.
• W3211316411 cites W2084281901 @default.
• W3211316411 cites W2091596103 @default.
• W3211316411 cites W2095068660 @default.
• W3211316411 cites W2098898636 @default.
• W3211316411 cites W2100980426 @default.
• W3211316411 cites W2111353167 @default.
• W3211316411 cites W2113049830 @default.
• W3211316411 cites W2116538568 @default.
• W3211316411 cites W2116807043 @default.
• W3211316411 cites W2119297241 @default.
• W3211316411 cites W2133917421 @default.
• W3211316411 cites W2133984874 @default.
• W3211316411 cites W2145651847 @default.
• W3211316411 cites W2146825681 @default.
• W3211316411 cites W2154746915 @default.
• W3211316411 cites W2155495720 @default.
• W3211316411 cites W2159425655 @default.
• W3211316411 cites W2161888715 @default.
• W3211316411 cites W2223012991 @default.
• W3211316411 cites W2239920470 @default.
• W3211316411 cites W2259398297 @default.
• W3211316411 cites W2270052372 @default.
• W3211316411 cites W2323754877 @default.
• W3211316411 cites W2326987869 @default.
• W3211316411 cites W2515338440 @default.
• W3211316411 cites W2533894695 @default.
• W3211316411 cites W2556909260 @default.
• W3211316411 cites W2748135641 @default.
• W3211316411 cites W2771591982 @default.
• W3211316411 cites W2808305854 @default.
• W3211316411 cites W2883958957 @default.
• W3211316411 cites W2887043640 @default.
• W3211316411 cites W2904631466 @default.
• W3211316411 cites W2905685521 @default.
• W3211316411 cites W2972173345 @default.
• W3211316411 cites W2973325642 @default.
• W3211316411 cites W3035189605 @default.
• W3211316411 cites W3048543675 @default.
• W3211316411 cites W3098633665 @default.
• W3211316411 cites W3108837502 @default.
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• W3211316411 doi "https://doi.org/10.1371/journal.pone.0259265" @default.
• W3211316411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8553083" @default.
• W3211316411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34710180" @default.
• W3211316411 hasPublicationYear "2021" @default.
• W3211316411 type Work @default.

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