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- W3211334977 endingPage "747" @default.
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- W3211334977 abstract "Due to their lack of multifunctionality, the majority of traditional wound dressings do not support all the clinical requirements. Bilayer wound dressings with multifunctional properties can be attractive for effective skin regeneration. In the present study, we designed a multifunctional bilayer scaffold containing Chitosan-Polycaprolactone (PC) nanofiber and tannic acid (TA) reinforced methacrylate gelatin (GM)/alginate (Al) hydrogel (GM/Al/TA). PC nanofibers were coated with GM/Al/TA hydrogel to obtain a bilayer nanocomposite scaffold (Bi-TA). The GM/Al/TA hydrogel layer of Bi-TA showed antibacterial, free radical scavenging, and biocompatibility properties. Also, PC nanofiber acted as a barrier for preventing bacterial invasion and moisture loss of the hydrogel layer. The wound healing performance of the Bi-TA scaffold was investigated via a full-thickness wound model. In addition, the histopathological and immunohistochemical (IHC) stainings of transforming growth factor-β1(TGF-β1) and tumor necrosis factor-α (TNF-α) were assessed. The results indicated an enhanced wound closure rate, effective collagen deposition, quick re-epithelialization, more skin appendages, and replacement of defect area with normal skin tissue by Bi-TA scaffold compared to other groups. Additionally, the regulation of TGF-β1 and TNF-α was observed by Bi-TA dressing. Overall, the Bi-TA with appropriate structural and multifunctional properties can be an excellent candidate for developing effective dressings for wound healing applications." @default.
- W3211334977 created "2021-11-08" @default.
- W3211334977 creator A5012257550 @default.
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- W3211334977 creator A5052725141 @default.
- W3211334977 creator A5072092771 @default.
- W3211334977 creator A5078139409 @default.
- W3211334977 date "2021-12-01" @default.
- W3211334977 modified "2023-10-10" @default.
- W3211334977 title "A novel multifunctional bilayer scaffold based on chitosan nanofiber/alginate-gelatin methacrylate hydrogel for full-thickness wound healing" @default.
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- W3211334977 doi "https://doi.org/10.1016/j.ijbiomac.2021.10.180" @default.
- W3211334977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34717980" @default.
- W3211334977 hasPublicationYear "2021" @default.
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