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- W3211341570 endingPage "102494" @default.
- W3211341570 startingPage "102494" @default.
- W3211341570 abstract "Multidrug resistance (MDR) in cancer chemotherapy is a growing concern for medical practitioners. P-glycoprotein (P-gp) overexpression is one of the major reasons for multidrug resistance in cancer chemotherapy. The P-gp overexpression in cancer cells depends on several factors like adenosine triphosphate (ATP) hydrolysis, hypoxia-inducible factor 1 alpha (HIF-1α), and drug physicochemical properties such as lipophilicity, molecular weight, and molecular size. Further multiple exposures of anticancer drugs to the P-gp efflux protein cause acquired P-gp overexpression. Unique structural and functional characteristics of nanotechnology-based drug delivery systems provide opportunities to circumvent P-gp mediated MDR. The primary mechanism behind the nanocarrier systems in P-gp inhibition includes: bypassing or inhibiting the P-gp efflux pump to combat MDR. In this review, we discuss the role of P-gp in MDR and highlight the recent progress in different nanocarriers to overcome P-gp mediated MDR in terms of their limitations and potentials." @default.
- W3211341570 created "2021-11-22" @default.
- W3211341570 creator A5004740492 @default.
- W3211341570 creator A5017543579 @default.
- W3211341570 creator A5063009687 @default.
- W3211341570 creator A5079081054 @default.
- W3211341570 creator A5089985940 @default.
- W3211341570 date "2022-02-01" @default.
- W3211341570 modified "2023-10-11" @default.
- W3211341570 title "Nanotherapeutics approaches to overcome P-glycoprotein-mediated multi-drug resistance in cancer" @default.
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